Prediction of ARrhythmic Events with Positron Emission Tomography-II (PAREPET-II)
This is a research study which will determine whether a series of tests can predict the
likelihood that your implantable cardiac defibrillator, or ICD, will deliver therapy for a dangerous heart rhythm.
If you choose to participate you will have one initial visit then we will follow-up with you by phone every three months for up to 5 years to check on your heart symptoms.
Study Visits will be in the UB Clinical and Translational Research Center, Downtown Buffalo.
Compensation is available. Your time and effort will be partially compensated by a
$60 gift card which you will receive after all testing is completed to cover the expense of
transportation and parking.
We have previously shown that a positron emission tomography (PET) scan to measure the nerve function in the heart can predict the likelihood of developing sudden cardiac arrest. The purpose of this new study is to determine if a combination of a similar PET scan, an echocardiogram and blood tests can more accurately predict the likelihood that you will have sudden cardiac arrest or your ICD delivers therapy. Since most people who receive an ICD do not use the device, we hope that this research will improve our ability to better identify those people who are most likely to use them. The PET scan will use a radioactive drug that has been approved by the FDA for research purposes only.
• Coronary artery disease (by cardiac catheterization or definite myocardial infarction)
• ICD implantation for the primary prevention of SCA
• Optimal medical therapy for heart failure [angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor antagonist (ARA)].
Let us know how the study team can reach you. If you do not hear back within 2 business days, reach out to the study team directly at the
contact information above or email firstname.lastname@example.org and someone will assist you.
Your information will be shared only with the research study team for recruitment purposes and designated CTSI personnel for project quality
assurance and will remain confidential. Your information will be stored indefinitely. Should you no longer want this information to be provided
in the aforementioned ways, please contact email@example.com.