This study enrolls children with type 1 diabetes. The study medication is called tepluzimab and has been administered to over 450 children with new onset T1D in prior trials and has shown promising improvement of beta cell function. The purpose of this study is to find out a definitive answer regarding the ability of teplizumab to help children with newly diagnosed type 1 diabetes in preserving their own insulin production. Read More

Children ages 8-17 years (up to when a child turns 18) old who have been diagnosed with Type 1 diabetes in the last 6 weeks.

This study enrolls children with Juvenile Idiopathic Inflammatory Myositis (JIIM). The purpose of this study is the learn more about whether ultrasound can be used as a tool to diagnose flares and remission. Read More

Children with an age at disease onset of less than 18 years old.
Have diagnosis of Juvenile Idiopathic Inflammatory Myositis.
Are a patient in the Infusion clinic at John R Oishei Children’s Hospital.

This study enrolls adults who have had a severe traumatic brain injury (TBI) who are in the Intensive Care Unit (ICU) at ECMC. The purpose of this study is to learn how the timing of giving patients with TBI a tracheostomy (putting a short tube directly into the trachea/windpipe through a small incision) can impact rates of ventilator associated pneumonia. Your participation in this study will involve receiving a tracheostomy as part of your usual care. If your doctors determine that you could benefit from a tracheostomy early in your care and you agree to the procedure, the tracheostomy will be performed. The study takes place at Erie County Medical Center. Compensation is not available for this study. Read More

Adults age 18+. Currently admitted to the Intensive Care Unit (ICU) at ECMC in Buffalo, NY. Diagnosed with traumatic brain injury (TBI) resulting from blunt or penetrating trauma. Requires endotracheal intubation to secure airway.

This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Compensation is not available for this study. Read More

Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.

We are looking for adults ages 18+ coming into Kaleida Health’s Gates Vascular Institute who have recently had a certain kind of mild stroke for this study (acute ischemic stroke that presents with mild symptoms). You would need to be enrolled into the study within 6 hours of when your symptoms begin. The purpose of this study is to find out which factors associated with the stroke make the condition worse. This will help us identify high-risk patients in the future. You will participate in this study for about 90 days. During the study you will not be asked to do anything additional- all the procedures involved in this study are routinely done with patients with stroke. If you decide to be in this study, we will gather data (for example, your history and vital signs) from your medical Read More

Age 18+.
Diagnosed with acute ischemic stroke.
At Kaleida Health-Gates Vascular Institute.
Enrolled within 6 hours from when symptoms begin.

This study is seeking only UB DEM emergency medicine physicians. UB Department of Emergency (DEM) and UB Primary Care Research Institute (PCRI) will perform a survey of emergency medicine physicians’ attitudes and beliefs about medication assisted treatment for opioid use disorder. Read More

DEM emergency medicine physicians in the academic division.

This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study. Read More

Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).

This study enrolls adults who have have a patent foramen ovale (PFO) and have had a stroke. The purpose of this study is to look at closing the PFO to reduce your risk for another stroke using a market-approved medical device called a septal occluder. Read More

Adults ages 18-70.
Patient has been evaluated by a neurologist and diagnosed with an ischemic stroke presumed to be an embolic stroke of undetermined source (ESUS) within the last 365 days prior to enrollment.
Patient has presence of a patent foramen ovale (PFO).

This study enrolls people with knee osteoarthritis. The purpose of this study is to learn whether weight impacts levels of pain and physical function in people with this condition. Read More

Adults ages 18+.
Individuals with self-reported or formally diagnosed osteoarthritis in at least one knee.
Individuals must have recurring pain in at least one knee at any time of the day (at rest, sleeping, after activity).
Individuals must be able to walk; however, the use of a cane is allowed.

This study enrolls adult men who have been diagnosed with prostate cancer. The purpose of this study is to learn why some patients treated for prostate cancer develop insulin resistance and to also learn about brain function in men with prostate cancer. Read More

Adult males ages 18+
Overweight (determined by body mass index greater than 25kg/m2)
Diagnosis of prostate cancer
Are either being treated with surgery/radiotherapy alone or are currently on Androgen Deprivation Therapy (ADT).
Healthy blood, kidney, and liver function (determined by bloodwork)
Able to read, write, and understand English language