This study enrolls adults who are scheduled to have an aortic valve replacement for disease the aortic valve called aortic stenosis. The Evolut PRO and Evolut PRO+ systems are FDA approved for treating aortic stenosis, so in this study we just want to collect data. The purpose of this study is to learn more about how well this device works. Read More

-Adults ages 18+.
-Have symptoms from aortic valve stenosis.
-Will be having aortic valve replacement.

This study enrolls people who have mitral regurgitation (MR). Mitral regurgitation happens when the heart’s mitral valve does not close tightly. The purpose of this trial is to evaluate a new investigational device called the Tendyne™ Mitral Valve System. The Tendyne Mitral Valve System is designed for the treatment of a diseased, damaged or malfunctioning mitral valve. This trial will collect information on how safe and effective this device is to treat a leaking mitral valve compared to the commercially available MitraClip® System. Read More

-Adults ages 18+.
-Have symptomatic, moderate-to-severe/severe mitral regurgitation (MR) or severe mitral annular calcification (MAC)
-Your medical providers have decided a transcatheter therapy is more appropriate than open surgery.

This study enrolls pregnant women who smoke cigarettes. The purpose of this study is to learn what types of smoking cessation (quit smoking) programs help women quit while also supporting breastfeeding. Read More

Adult women, ages 18+.
Currently pregnant (at 29 weeks of pregnancy or earlier).
Have smoked 1+ cigarettes per day in the past week.
Must enroll with a family support person (a partner or family member). This person must have a close relationship and frequent contacts with the pregnant woman and be willing to support breastfeeding.

This study enrolls people who are scheduled for a surgery at ECMC involving removing the tissue that makes saliva. The purpose of this study is to use tissue samples that otherwise would have been discarded to learn more about how salivary gland inflammation happens at a molecular level. We hope this will lead to new ways to diagnose and treat salivary gland inflammatory diseases. Read More

Adults ages 18+
Scheduled for a surgery at ECMC involving salivary gland excision (e.g. Neck Dissection Surgery, etc.)
Any sample of salivary gland tissue that would otherwise be discarded will be included for the study.

This study enrolls current patients who have MS. The purpose of this study is to gain a better understanding of Severely Affected Patients with MS to lead to better early identification, treatment and care. Read More

Adults ages 30-75.
Must have been invited to participate by a provider.

This study enrolls people who have had a stroke or who have epilepsy who are being seen at Buffalo General Hospital. We want to learn more about how a patient’s understanding of the disease, treatment and other factors prevent future medical events. Read More

Adults ages 18+.
Must have confirmed diagnosis of stroke or seizure disorder.
Presents for stroke or seizure at Buffalo General Medical Center.

This study enrolls people who have been treated with Radiation therapy for larynx, pharynx, nasopharynx, tonsil & base of tongue cancer who have trouble swallowing. The purpose of this study is to develop a better method to collect swallow pressure information, which may replace current less precise techniques. Read More

Ages 18+.
People with the following cancers: Nasopharyngeal, Laryngeal, Oropharyngeal, Hypo-pharyngeal, Base of Tongue, & Tonsilar.
Must have completed an entire Radiotherapy cycle.
Have dysphagia (swallowing difficulties).
Must be able to undergo speech therapy alone or speech therapy + esophageal dilation dilation as part of their rehabilitation treatment plan.

This study enrolls people who need tube shunt implantation for the treatment of their severe glaucoma. The purpose of this study is to learn which type of tube shunt (a device used during the surgery) works the best. Read More

Adults ages 18+.
Have significant uncontrolled glaucoma despite medical, laser or previous surgery that requires tube shunt implantation.
Are scheduled for glaucoma tube shunt implantation surgery.

This study enrolls adults who have not been diagnosed with diabetes. The purpose of this study is to look at decision making and how it relates to food, exercise, and blood sugar levels. Read More

Adults 18+
Normal glucose levels or a diagnosis of prediabetes.

This study enrolls pregnant women taking methadone or buprenorphine for opioid use disorder. The purpose of this study is to learn about the factors that can promote or prevent successful breastfeeding in these women from the perspective of the woman. We also want to explore how those factors change over time. Read More

Woman ages 18+.
Must be pregnant and intend to breastfeed their newborn.
Stable on opioid maintenance therapy for opioid use disorder.