This clinical study investigates a new treatment for prostate cancer. ODM-208 (CYP11A1 inhibitor) is the oral study medication that will be taken together with oral glucocorticoid (dexamethasone) and mineralocorticoid (fludrocortisone) replacement therapy. The purpose of this study is to find a safe and effective dose of ODM-208 for the treatment of prostate cancer. The purpose of this study is also to use the results of this study to support development programs of CYP11A1 inhibitors in prostate cancer and other relevant indications. Read More

1) Males greater than or equal to 18 years. 2) Metastatic disease documented either by a positive bone scan, CT, PET/CT or MRI scan 3) Treatment with at least 1 line of taxane-based chemotherapy in castration-sensitive prostate cancer (CSPC) or in CRPC

The purpose of this study is to examine the effects of hot and ambient water immersion on 1) resting brain blood flow and 2) the brain blood flow response to decreases and increases in carbon dioxide in the blood. There will be 3 visits at UB South Campus: an informed consent/screening visit (30-60 minutes) and two experimental visits (5 hours each) at least 7 days apart. You will be seated in a pool with water up to your neck and your arms will be immersed in the water. Prior to, during, and after the water immersion, we will obtain a venous blood sample and you will complete a breathing test to measure your brain blood flow. Read More

Women
18-40 years old
Healthy

-Adults ages 18-80
-Has a single unruptured target intracranial aneurysm (IA) located on the internal carotid artery (ICA) or its branches.

This study is being done to see if the Buffalo Concussion Physical Exam and the Tele-Brain Injury Screen can be safely used to identify brain injury and its impact on functioning in female survivors who have experienced intimate partner violence. The Buffalo Concussion Physical Exam is a non-invasive physical exam that examines neck/head area for any discomfort. This exam also tests standing balance and the ability to follow movements with eyes. The Tele-Brain Injury Screen tells us how individuals suspected of brain injury are feeling and whether the way they are feeling is interfering with their functioning. In essence, we want to understand if intimate partner violence could result in brain injury. We also want to understand the effects of brain injury on daily functioning and social functioning. Read More

18-60 years old
Proficient in English
Physical injury to head/neck/face or strangulation injury due to partner abuse within the past year
Reports of physical abuse (e.g., being thrown against an object, partner initiated fall resulting in head injury or any other reports of physical abuse resulting in whiplash injury) by an intimate partner within the past year
Phys...

This survey study examines how transgender and gender nonconforming individuals have experienced oral healthcare, how accessible such care is to them, and how they feel about receiving it. Read More

18 or greater years of age
self-identify as transgender or gender nonconforming

Participants 1-24 months old at Oishei Children's Hospital Emergency Deparment (ED) with suspected Bronchiolitis may be eligible for this study. Once enrolled, participants will undergo two carbon dioxide measurements, first will be done upon ED arrival at the Triage room, and the second one will be done upon ED discharge at patient's private room. Otherwise, participant will receive routine clinical care. Read More

Children ages 1-24 months old.
Have respiratory signs and symptoms and suspected bronchiolitis.

This is a study to evaluate the efficacy of Chemo Mouthpiece® in minimizing patient-reported symptoms associated with oral mucositis in cancer patients receiving chemotherapy. The Chemo Mouthpiece(R) is a novel device to make it easier to deliver cryotherapy (ice chips). Read More

Aged 18-80 years
Planned to receive at least 2 cycles of infused stomatotoxic chemotherapy regimens
Be willing and able to complete all study-related activities

An early feasibility study to evaluate the safety and efficacy of Delphi Revascularization device for clot retrieval. This is for hospital patients with Anterior circulation ischemic stroke. Up to 8hrs of symptom onset or last known well time. Read More

At least 18 years of age at time of consent;
The patient or patient’s LAR has signed and dated an ICD using the Institutional Review Board (IRB) and Medtronic Approved ICD and agrees to comply with protocol requirements. Health Insurance Portability and Accountability Act of 1996 (HIPAA) authorization has been provided and signed by the patient or patient’s LAR
Has baseline N...

The purpose of this study is to identify promising treatments and compare them to determine which are most effective and then move into studies that can prove their effectiveness. The study will be conducted at up to 40 sites throughout the US with 200 patients being enrolled. Participants will receive one of several investigational products and then be evaluated for outcomes related to their overall improvement. They will be monitored at all times for safety and any adverse reactions to the products. Read More

Admitted to a hospital with symptoms suggestive of COVID-19 and requires ongoing medical care.
Subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures.
Subject (or legally authorized representative) understands and agrees to comply with planned study procedures.
Male or non-pregnant female adult ≥18 years of age at t...

This study enrolls children and adults with skin conditions such as Atopic Dermatitis (eczema). The purpose of this study is to learn more about people who have been diagnosed with these conditions, including information about their health and the medications they take to manage their disease. Specifically, we want to understand how different treatments may affect the health of some patients differently than others. Read More

Adults or children.
Being prescribed medical therapy for atopic dermatitis.