We are enrolling children ages 12-17 and their parents in this research study. The purpose of this study is to learn about knowledge about e-cigarettes, vaping, the risk of using these devices, as well as parents awareness about their children's status for using these devices. Read More
-Children ages 12-17 their accompanying parent or guardian.
-Currently receiving care at the Emergency Department at Oishei Children's Hospital.
-Must have a grade 6 English reading level.
A concussion is a mild traumatic brain injury that may result in a variety of symptoms including headaches and vision, balance, cognitive or mood-related problems. Due to this wide range of symptoms, concussions may be difficult to diagnose and treat. The goal of this study is to create a registry of patients interested in participating in research so we can identify the best treatment approach to specific concussion presentation types. Read More
1. Any sex or gender
2. Aged 7 years or older
3. Agree to participate in the concussion patient registry
4. Has had a concussion
This clinical trial is exploring the use of an investigational drug (sGC stimulator vericiguat/MK-1242) in patients with chronic heart failure. Specifically, trial doctors are interested in assessing the safety of this drug and if it works well to lower some of the risks of heart failure. All participants will be able to stay on their current heart failure medication during the 2-year trial period. Read More
1) History of chronic stable, NYHA class II to IV CHF
2) NT-proBNP 600 - 6000
3) LVEF of <40% assessed within 12 months before randomization
This clinical trial is seeking to enroll patients with curved spines or other anatomic spinal problems. The goal of this trial is to determine whether placing a device, called iFuse-3D, into the sacrum and ilium (pelvis) bone during multilevel spine fusion (MLF) surgery provides benefits compared to not using this device. During MLF surgery, a spine surgeon places rods and screws in the spine in an attempt to straighten the spine and correct other spinal problems. The surgeon also places screws into the sacrum and pelvis bone. This may result in a decrease in pain and a restoration of the normal curvature of the spine. This is a multicenter trial with up to 35 hospitals in the US, Europe, and Australia. This study hopes to enroll 220 patients. If you participate, the study requires you to participate for two years with in-person visits between 2-6 weeks post-operation and at 6, 12 and 24 months. Read More
1. Age 21-75 at time of screening
2. Patient scheduled for multilevel (4 or more levels) spinal fusion surgery with planned fixation to the pelvis using S2AI screws
3. Patient has signed study-specific informed consent form
4. Patient has the necessary mental capacity to participate and is physically able to comply with study protocol requirements
The goal of the UB Eating Among Teens Study (UB EATS) is to measure eating behaviors and neighborhood and household factors in 11 - 14-year-olds over the course of 3 years. Participation involves 7 visits to the UB Nutrition and Health Research Lab on South Campus over the 3-year period to answer questionnaires and eat snack foods. Low and middle-income families are encouraged to apply. Read More
-Adolescents ages 11 to 14
-Low to moderate income households
-No medical conditions or medications that impact appetite
-No allergies to study foods such as cookies, candy and potato chips
-Planning to live in the Western New York area for the next two years
-Willing to attend baseline and follow-up visits at a local research center
A hot work environment can lead to fatigue, hyperthermia, and dehydration, which may increase injury risk and reduce productivity. The goal of this study is to learn more about the body’s response to repeated days of working in a hot and humid environment. Participation will involve 7 visits to the UB South Campus for repeated days of 8-hour periods of sitting or performing moderate-high intensity work in a hot and humid room. Read More
The goal of this study is to evaluate the safety, effectiveness and tolerability of a drug compound (AVP- 786) for the treatment of agitation associated with Alzheimer’s Disease. Alzheimer’s Disease causes loss of brain cells and problems with memory, thinking and behavior. Agitated behaviors, such as irritability and restlessness, physical and verbal aggression, and pacing and wandering are major problems in this condition, can be difficult to manage, and can impact your quality of life. AVP-786 is targeted at treating your agitation behaviors. Caregivers are being asked to take part in this research study because the participants may require assistance to complete study procedures and/or attend study visits. Participation in this study will last for approximately 20 weeks and include site visits throughout the study. Read More
Patients 50 to 90 years of age (inclusive) with clinically significant, moderate-to-severe agitation for at least 2 weeks prior to screening that interferes with daily routine per the Investigator's judgment, and who require pharmacotherapy for the treatment of agitation per the Investigator's judgment after an evaluation of reversible factors and a course of nonpharmacological interventions.
This study looks at the safety and efficacy of the combination of Pembrolizumab, Carboplatin, & Paciltaxel for patients with incurable head and neck cancer that has returned after being treated or has spread to other body parts. The study will take place at ECMC and can last 2-3 years. Read More
-Has histologically or cytologically-confirmed diagnosis of recurrent / metastatic head and neck squamous cell carcinoma (HNSCC) that is considered incurable by local therapies.
-Has not had prior systemic therapy administered in the recurrent or metastatic setting.
Systemic therapy, which was completed more than 6 months prior to signing consent,
if given as part of multimodal treatment f...
We are looking for adults ages 18-40 for this study. We are looking for people in general good health and also people who have had a history of blast exposure and blunt head trauma. The purpose of this study is to learn more about balance in people with a history of blast exposure and blunt head trauma compared to healthy people. You will participate in this study for one session that lasts about 3 hours. During the study you will complete balance, vision, and stability tests in our lab. Study visit takes place in the Department of Rehabilitation Science lab at UB's South Campus. Participants will be compensated. Read More
-Adults ages 18-40.
-Generally healthy OR have had a history of impact brain injury/head trauma in past ten years.
This study enrolls students who participate in the after-school program at a local Buffalo community location. The purpose of this study is to look at reading and literacy skills after a computer based newsletter program. Read More
-Children ages 10-13.
-Must be in the after-school program at a participating local Buffalo community center in grades 6-8.
-Must have access to a computer: laptop, Chromebook, or desktop with the capability to download Zoom.
-Must have internet access at home or center.