This study will look how safe and effective the investigational drug firibastat (not yet approved for market) is. On top of your current medication, you will receive either firibastat(half of all participants) or placebo (half of all participants) for the first 12-weeks followed by open-label study treatment with firibastat for 24 or 36-weeks; the placebo looks exactly the same as the investigational drug, but contains no active medicine. The group you are in will be selected at random. The study medication and placebo will be taken by mouth once daily. Read More
Must be >=18 years of age
Diagnosis of primary hypertension (high blood pressure) for at least 6 months prior to screening
Currently treated with at least 2 high blood pressure medications
Have a systolic office blood pressure between 140 mmHg and 179 mmHg at screening
Have a systolic home blood pressure with a mean 135 mmHg after the run-in period
We are studying metabolism while marching with a heavy military backpack in dry and humid environments. Your first 3 visits will consist of completing questionnaires, a health screening & a series of exercises. During the following 6 visits you will perform treadmill walking while carrying a heavy military backpack. Read More
Healthy, physically active females (18-39 y) who pass the Occupational Physical Assessment Test (OPAT) with at least a gray score in each task (significant job requirement) will be eligible to participate. To ensure that extraneous variables do not impact study results, subjects will be excluded from participation for any of the following reasons:
- History of cardiovascular, metabolic, resp...
Patients who use cannabis on a regular basis may be at a greater risk for sedation-related complications. In our dental sedation suite, we routinely sedate patients for oral surgery three days per week. We have recently noted an increase in patients who use cannabis regularly. This study will gather self-reported cannabis use history via a questionnaire, and analyze sedation records to assess cannabis use's effect on sedation. Read More
-18 or greater years of age and report to our oral surgery clinic for treatment.
-Able to consent to their own medical treatment.
-Willing to sign informed consent and complete the questionnaire.
-Able to comprehend the content of the questionnaire and consent form in English.
We are seeking Transradial amputee’s participation in a research study aiming to evaluate a novel controller for a prosthetic wrist. This study investigates the performance of the controller during activities of daily living in a virtual reality environment. Upper limb movement and muscle activation will also be collected using Motion Capture Systems and different types of sensors. Study will be done at Furnas Hall 809, AWEAR Lab, University at Buffalo North Campus. Read More
- 18 years old or above and have unilateral or bilateral upper limp amputation
- Current and/or New user of any type of prosthetic device
- Non-user of prosthetic devices who have been previously fit but have chosen not to wear it
Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More
-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.
Study to assess the effect of dapagliflozin as compared with placebo in patients with heart failure who have been stabilized during hospitalization for acute heart failure. Patients will be followed for a maximum of 2 months. Read More
1. Currently hospitalized with AHF with symptoms of AHF.
2. LVEF <40% within the past 12 months
3. Elevated NT-proBNP, >1600 pg/ml
4. > 18 years of age
5. eGFR >30
We invite you to participate in this research study because you've been diagnosed with a spinal condition requiring surgery using pedicle screw instrumentation in your lumbar spine. Your surgeon plans to use the VersaTie tether to prevent breakdown above your spine surgery. The VersaTie tether provides a gradual transition from the unfused to fused spine. The study procedure will take place at Gates Vascular Institute. Read More
1. >18 years of age at the time of treatment
2. EOS full body or standing 36” AP & Lateral images of entire spine
3. Posterior spine fusion with pedicle screw fixation construct of 5 or more levels
4. Pedicle screw fixation to be supplemented proximally with NuVasive VersaTie system
5. Upper instrumented vertebra (UIV) terminating at a newly instru...
The purpose of the study is to see how best to educate people about kidney transplantation and donation. The ECMC kidney patient will get an email invitation to participate. Participant will then fill out a few online surveys and watch several short videos about kidney transplantation / donation for about an hour. Participant will be paid up to $200. Read More
Advanced kidney failure
Adult patients with cerebral palsy will be walking on ground and a treadmill. Participants will wear a belt on their waist with sensors connected to a robot. There will be unpleasant sounds generated to provide cues to change walking pattern. Study will take place at UB for six sessions and will take two hours for each session. Read More
This study enrolls people who have suffered a stroke in the past 24 hours. The purpose of this study is to learn if a patient can benefit from a clot removal procedure if they have a stroke scale of 5 or lower. Read More
-Adults ages 18+
-Diagnosed with acute ischemic stroke and have an objective neurological deficit.