Hard physical work and intense exercise is heavily fueled by carbohydrates like bread and fruit. The goal of this study is to determine how fat and carbohydrates are burned while wearing a heavy pack and walking/fast running in the heat. Information from this study may directly affect nutrition and training recommendations for military and first responders. Read More

This study is enrolling participants with a form of breast cancer (HER2-positive breast cancer) to investigate the effectiveness and safety of a medication combination (adjuvant atezolizumab when given in combination with trastuzumab emtansine). This new drug combination may decrease the chances of breast cancer recurrence. Read More

1) Age greater than or equal to 18 years at time of signing the Informed Consent Form
2) Histologically confirmed invasive breast carcinoma
3) Diagnosis of HER2-positive breast cancer with assessment of hormone receptor and PD-L1 status
4) Completion of preoperative systemic chemotherapy and HER2-directed treatment
5) Adequate excision: surgical removal of all clinically eviden...

This study is being used to evaluate a new troponin blood test. Troponin blood tests are used in emergency departments as part of the diagnosis for heart attack. Patients presenting to the emergency department with chest pain or heart attack equivalent symptoms will be invited to participate. Blood draws will occur 5 times during the patient's emergency department visit. The results of the blood test will not be available to the treating provider, and will have no effect on patient care. Read More

1. Patients seeking emergency care in participating emergency department

2. Signed Informed Consent

3. Age: 20 or more years

4. Subjects demonstrating symptoms suggestive of acute coronary syndrome and/or myocardial ischemia or Asymptomatic subjects or patients with atypical symptoms in whom myocardial infarction is being suspected

5. Troponin or other cardi...

This study enrolls people who have head and neck cancer or tumor. The purpose of this study is to learn about whether levels of HPV (Human Papillomavirus) and a protein (P16) are related to the way people respond to treatment for head and neck cancer. Read More

-Patients at least 18 years of age.
-Patients who have been diagnosed with head and neck squamous cell carcinoma.
-Patients who have a pre-treatment biopsy of a pathologically confirmed p16/HPV positive tumor.

For 18-45 year old women undergoing gynecology surgery at Kaleida Health. A sliver of tissue and a tablespoon of fluid will be removed from womb lining which will take less than 5 minutes. This tissue and pelvic fluid will be used to examine cells, and measure hormones / inflammatory proteins. Patients will also be told whether or not there is endometriosis. Read More

-Reproductive age women (18-45 years old)
-Regular menstrual cycles
-Undergoing indicated gynecological surgery, including tubal sterilization, evaluation of pelvic pain or pelvic mass

The goal of this study is determine the difference in quality of life in tree nut-allergic patients before and after clearing of allergy label for subgroups of tree nuts compared to those who completely avoid all tree nuts. This will be done via questionnaires given to patients and parents at clinic visits. Read More

Patient ages 0 to 17 years seen at UBMD Pediatrics Allergy/Immunology, who have a diagnosis of a tree nut allergy to one or more of the aforementioned tree nuts will be eligible to enroll in the study

This clinical trial is exploring the use of an investigational drug (sGC stimulator vericiguat/MK-1242) in patients with chronic heart failure. Specifically, trial doctors are interested in assessing the safety of this drug and if it works well to lower some of the risks of heart failure. All participants will be able to stay on their current heart failure medication during the 2-year trial period. Read More

1) History of chronic stable, NYHA class II to IV CHF 2) NT-proBNP 600 - 6000 3) LVEF of <40% assessed within 12 months before randomization

The goal of the UB Eating Among Teens Study (UB EATS) is to measure eating behaviors and neighborhood and household factors in 11 - 14-year-olds over the course of 3 years. Participation involves 7 visits to the UB Nutrition and Health Research Lab on South Campus over the 3-year period to answer questionnaires and eat snack foods. Low and middle-income families are encouraged to apply. Read More

-Adolescents ages 11 to 14

-Low to moderate income households

-No medical conditions or medications that impact appetite

-No allergies to study foods such as cookies, candy and potato chips

-Planning to live in the Western New York area for the next two years

-Willing to attend baseline and follow-up visits at a local research center

-Ad...

A hot work environment can lead to fatigue, hyperthermia, and dehydration, which may increase injury risk and reduce productivity. The goal of this study is to learn more about the body’s response to repeated days of working in a hot and humid environment. Participation will involve 7 visits to the UB South Campus for repeated days of 8-hour periods of sitting or performing moderate-high intensity work in a hot and humid room. Read More

Males and females ages 18-39

The goal of this study is to evaluate the safety, effectiveness and tolerability of a drug compound (AVP- 786) for the treatment of agitation associated with Alzheimer’s Disease. Alzheimer’s Disease causes loss of brain cells and problems with memory, thinking and behavior. Agitated behaviors, such as irritability and restlessness, physical and verbal aggression, and pacing and wandering are major problems in this condition, can be difficult to manage, and can impact your quality of life. AVP-786 is targeted at treating your agitation behaviors. Caregivers are being asked to take part in this research study because the participants may require assistance to complete study procedures and/or attend study visits. Participation in this study will last for approximately 20 weeks and include site visits throughout the study. Read More

Patients 50 to 90 years of age (inclusive) with clinically significant, moderate-to-severe agitation for at least 2 weeks prior to screening that interferes with daily routine per the Investigator's judgment, and who require pharmacotherapy for the treatment of agitation per the Investigator's judgment after an evaluation of reversible factors and a course of nonpharmacological interventions. A...