The University at Buffalo (UB) Department of Exercise and Nutrition Sciences is looking for healthy adult volunteers to participate in an exercise study. The goal of the study is to look at bodily changes that wildland firefighters experience when working in different hot conditions. Read More

Healthy adults 18-39 years old Exercise regularly (at least 2.5 hours of moderate exercise a week or 1.25 hours of vigorous exercise per week) Not currently using tobacco products or have regularly used in the last 2 years Not currently pregnant or breastfeeding Does not have hypertension (high blood pressure) or tachycardia (heart that beats faster than normal, greater than 100 beats per minu...

This study is recruiting volunteers for a dental study through the University at Buffalo (UB) Microbiome Center in the UB School of Dental Medicine. The study team is researching if they can make accurate copies of bacteria patterns in mouth plaque (the “stuff” that collects between gums and teeth). The results of the study will help dentists to better understand how gum disease develops and comes back over time. Read More

1. At least 21 years old 2. Have at least sixteen (16) teeth 3. Not currently pregnant 4. Not currently wearing braces or orthodontic appliances

The UB Jacobs School of Medicine and Biomedical Sciences, Division of Behavioral Medicine (DBM) is looking for adult volunteers to participate in the EPPIC (Easing Pelvic Pain Interventions Clinical Research Program). The goal of this National Institutes of Health (NIH)-funded study is to determine the effectiveness of different behavioral therapies for controlling urologic chronic pelvic pain syndrome (UCPPS), why they work, for whom they are most effective, and durability of treatment gains (or how long they last). This is a non-drug treatment study and volunteers will receive payment for their participation in the study. Read More

1) Male or females between the ages of 18-70 years old 2) Experience pelvic pain symptoms for at least 3 months 3) Diagnosis of interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPP) 4) Access to a telephone and computer/smartphone 5) Reliable transportation

This study is recruiting patients diagnosed with rapid-onset dystonia-parkinsonism (RDP). RDP is a rare movement disorder. It has symptoms of both dystonia (lasting muscle contractions) and Parkinson’s Disease (presence of tremor in one hand and a stiffness or slowing of movement). Patients may develop RDP suddenly or gradually over time. Read More

1) Patients with known/suspected RDP gene mutation OR those who have been identified as carriers/family members of someone with an RDP gene mutation 2)Patients who were previously enrolled in an earlier version of this study 3) 18 months of age or older 4) Access to Wi-Fi and a smart device (for example, a smartphone, laptop, tablet)

This study is for children ages 7 – 17 years old admitted to the Oishei Children’s Hospital emergency room (ER) who are experiencing nausea/vomiting. The goal of the study is to see if a different treatment (inhaled isopropyl alcohol) works better than the medication typically used (Zofran) for treating nausea/vomiting in pediatric patients. Read More

1. 7-17 years old

2. Chief complaint of nausea or vomiting

3. Weight >=15 kg (~33lbs)

4. BARF (nausea severity score) >=4/10

5. Admitted to the Oishei Children's Hospital emergency room

This study is being used to evaluate a new troponin blood test. Troponin blood tests are used in emergency departments as part of the diagnosis for heart attack. Patients presenting to the emergency department with chest pain or heart attack equivalent symptoms will be invited to participate. Blood draws will occur 5 times during the patient's emergency department visit. The results of the blood test will not be available to the treating provider, and will have no effect on patient care. Read More

1. Patients seeking emergency care in participating emergency department

2. Signed Informed Consent

3. Age: 20 or more years

4. Subjects demonstrating symptoms suggestive of acute coronary syndrome and/or myocardial ischemia or Asymptomatic subjects or patients with atypical symptoms in whom myocardial infarction is being suspected

5. Troponin or other cardi...

This study enrolls people who have head and neck cancer or tumor. The purpose of this study is to learn about whether levels of HPV (Human Papillomavirus) and a protein (P16) are related to the way people respond to treatment for head and neck cancer. Read More

-Patients at least 18 years of age.
-Patients who have been diagnosed with head and neck squamous cell carcinoma.
-Patients who have a pre-treatment biopsy of a pathologically confirmed p16/HPV positive tumor.

For 18-45 year old women undergoing gynecology surgery at Kaleida Health. A sliver of tissue and a tablespoon of fluid will be removed from womb lining which will take less than 5 minutes. This tissue and pelvic fluid will be used to examine cells, and measure hormones / inflammatory proteins. Patients will also be told whether or not there is endometriosis. Read More

-Reproductive age women (18-45 years old)
-Regular menstrual cycles
-Undergoing indicated gynecological surgery, including tubal sterilization, evaluation of pelvic pain or pelvic mass

The goal of this study is determine the difference in quality of life in tree nut-allergic patients before and after clearing of allergy label for subgroups of tree nuts compared to those who completely avoid all tree nuts. This will be done via questionnaires given to patients and parents at clinic visits. Read More

Patient ages 0 to 17 years seen at UBMD Pediatrics Allergy/Immunology, who have a diagnosis of a tree nut allergy to one or more of the aforementioned tree nuts will be eligible to enroll in the study

This clinical trial is exploring the use of an investigational drug (sGC stimulator vericiguat/MK-1242) in patients with chronic heart failure. Specifically, trial doctors are interested in assessing the safety of this drug and if it works well to lower some of the risks of heart failure. All participants will be able to stay on their current heart failure medication during the 2-year trial period. Read More

1) History of chronic stable, NYHA class II to IV CHF 2) NT-proBNP 600 - 6000 3) LVEF of <40% assessed within 12 months before randomization