This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study. Read More
Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).
This study enrolls people with knee osteoarthritis. The purpose of this study is to learn whether weight impacts levels of pain and physical function in people with this condition. Read More
Adults ages 18+.
Individuals with self-reported or formally diagnosed osteoarthritis in at least one knee.
Individuals must have recurring pain in at least one knee at any time of the day (at rest, sleeping, after activity).
Individuals must be able to walk; however, the use of a cane is allowed.
This study is for people undergoing surgery for mitral regurgitation (MR). Mitral regurgitation is a condition when your heart’s mitral valve does not close tightly which causes blood to flow backwards in your heart. The purpose of this study is to learn how safe and effective one value repair system is (the PASCAL System, an investigational device) compared to another one (the MitraClip System). Read More
Adults ages 18+.
Have severe degenerative mitral regurgitation, and are considered prohibitive risk for mitral valve surgery by your heart team.
This study enrolls overweight people with knee arthritis. The purpose of this study is to learn if weight-loss surgery before total knee replacement leads to fewer short-term and long-term complications. Read More
Adults ages 22-75
Diagnosed with osteoarthritis of the knee and in need of total knee replacement
Overweight (determined by body mass index measurement)
Able to walk
The purpose of this study is to learn about which operating room layout is best when using robot-assisted surgery (RAS). We want to learn which layout is the most efficient and best for communication, teamwork, and patient safety. Read More
-Surgical team members from selected institutions.
This study enrolls adults who are current or past residents of the Town or City of Tonawanda or Grand Island. The purpose of this study is to learn about the health of our community and the diseases that people in our community have. We also want to learn if pollution is linked with diseases and how to reduce diseases in people who were exposed to pollution. Read More
Adults ages 18+.
Current or past residents of Grand Island, the City of Tonawanda, or the Town of Tonawanda.
We are looking for healthy children aged 4 to 5 (and their parent) to participate in a study to measure children’s reactions to different activities like playing games, eating snacks, and playing with a parent. Read More
Children ages 4-5.
Parent age at least 18.
-At least 1 parent who is considered overweight (by height/weight measurement).
-Parent and child fluent in English.