This is a single-center, randomized, open label, placebo controlled clinical trial. Patient who visit our ER and needs blood work or IV line placement may be eligible for the study. Subject enrolled in the study will have an equal chance to be assigned into one of the four study groups for pain relief during the needle stick, i.e. shot blocker, buzzy bee, vapocoolant, or placebo. Totally 220 subjects will be enrolled in the study, with 55 in each group. The PI hypothesizes that the Vapocoolant may not be as effective as the buzzy bee or shot blocker in pain relief. Read More
Children ages 6-18 years old.
Visiting ED at Oishei Children's Hospital and need blood work or IV line placement.
This study enrolls adults ages 18-65 who have the symptoms of an ischemic stroke. An ischemic stroke is caused by a clot in a blood vessel that blocks blood flow to a certain part of the brain. The purpose of this study is to learn more about if people with this type of stroke do better when their blockage is removed within 24 hours of the stroke starting. Read More
Adults ages 18-65.
Presenting to the hospital with symptoms consistent with an acute ischemic stroke.
This study enrolls people who participate in services that the Hearts and Hands organization provides. The purpose of this study is to learn about the impact of using voice-command devices (VCD) on loneliness and depressive symptoms in older adults with reduced community mobility. By providing older adults with means to maintain social connections and improve well-being, we may find a new way to improve mental health in socially isolated older adults. Read More
Adults ages 60+.
Must be receiving Hearts & Hands volunteer organizations' driving service.
Must not have a pet.
Must live alone.
This study enrolls children and adults who have tested positive for COVID-19. The purpose of this study is to collect and bank blood samples of people who have COVID-19. We will analyze these samples to understand more about the virus. Read More
Adults or children
Positive for SARS-CoV-2 or highly suspicious for SARS-CoV-2 (symptoms with known contact).
This study enrolls children with Juvenile Idiopathic Inflammatory Myositis (JIIM). The purpose of this study is the learn more about whether ultrasound can be used as a tool to diagnose flares and remission. Read More
Children with an age at disease onset of less than 18 years old.
Have diagnosis of Juvenile Idiopathic Inflammatory Myositis.
Are a patient in the Infusion clinic at John R Oishei Children’s Hospital.
This study enrolls adults who have had a severe traumatic brain injury (TBI) who are in the Intensive Care Unit (ICU) at ECMC. The purpose of this study is to learn how the timing of giving patients with TBI a tracheostomy (putting a short tube directly into the trachea/windpipe through a small incision) can impact rates of ventilator associated pneumonia. Your participation in this study will involve receiving a tracheostomy as part of your usual care. If your doctors determine that you could benefit from a tracheostomy early in your care and you agree to the procedure, the tracheostomy will be performed. The study takes place at Erie County Medical Center. Compensation is not available for this study. Read More
Adults age 18+. Currently admitted to the Intensive Care Unit (ICU) at ECMC in Buffalo, NY. Diagnosed with traumatic brain injury (TBI) resulting from blunt or penetrating trauma. Requires endotracheal intubation to secure airway.
This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Compensation is not available for this study. Read More
Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.
We are looking for adults ages 18+ coming into Kaleida Health’s Gates Vascular Institute who have recently had a certain kind of mild stroke for this study (acute ischemic stroke that presents with mild symptoms). You would need to be enrolled into the study within 6 hours of when your symptoms begin. The purpose of this study is to find out which factors associated with the stroke make the condition worse. This will help us identify high-risk patients in the future. You will participate in this study for about 90 days. During the study you will not be asked to do anything additional- all the procedures involved in this study are routinely done with patients with stroke. If you decide to be in this study, we will gather data (for example, your history and vital signs) from your medical Read More
Diagnosed with acute ischemic stroke.
At Kaleida Health-Gates Vascular Institute.
Enrolled within 6 hours from when symptoms begin.
This study is seeking only UB DEM emergency medicine physicians. UB Department of Emergency (DEM) and UB Primary Care Research Institute (PCRI) will perform a survey of emergency medicine physicians’ attitudes and beliefs about medication assisted treatment for opioid use disorder. Read More
DEM emergency medicine physicians in the academic division.
This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study. Read More
Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).