Study for Healthy Volunteers OR People in the Hospital for a Cardiovascular Issue
Protocol: STUDY00004790
Full Title
Functional effect of therapeutic stem cell-derived extracellular vesicles on human peripheral blood mononuclear cells
Description
This study enrolls adults who have had heart failure or heart attack or who are generally healthy. The purpose of this study is to learn more about how these types of cardiovascular issues happen at a biological level. We will do that by looking at the immune cells in the blood.

This study takes about 30 minutes. You will give a total of 4 blood samples in this one-time study. Study takes place in Kaleida facilities in Buffalo, NY.

Technical Description

We are trying to better understand a clinically relevant treatment for cardiovascular diseases and discover the underlying mechanisms through which it works. The goal of this study is to isolate and treat human immune cells found in the blood with extracellular vesicles (small particles released from cells in our bodies) derived from stem cells. Immune cells, particularly monocytes, are important in our bodies response to injury. We are trying to determine how these extracellular vesicles affect immune cell, and particularly monocyte, function.
Compensation: No
Eligibility
Adults ages 18+
Generally healthy OR are presenting to the hospital with heart failure or acute myocardial infarction (heart attack).
Age Group: Adults
Principal Investigator: JENNIFER LANG
Contact(s)
KYLE MENTKOWSKI
kylement@buffalo.edu
+1 716-645-8500
Want to Learn More?
Let us know how the study team can reach you. If you do not hear back within 2 business days, reach out to the study team directly at the contact information above or email ctsiresearch@buffalo.edu and someone will assist you.