Inter-species and host-derived cues that modulate colonization of Porphyromonas gingivalis
Study will assess adult participants for gum disease and bacteria in the mouth. The dental exams are the same exams that normally take place in dentist’s office. Saliva and plaque will be collected from participants. Visits will be every 2 weeks or every month. Study lasts 10-12 months.
This prospective longitudinal observational study will identify microbial species that serve as putative modulators of Porphyromonas gingivalis (Pg) colonization through analysis of time-series metagenomic data via dynamical systems models. The study will also evaluate the role of the microbiome functional capabilities and heme availability on Pg levels.
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At least 25 years old
At least sixteen (16) teeth
To be determined at Screening Visit: Presence of at least 4 sites (anterior or posterior) with probing pocket depths (PD) > 5 mm and < 6 mm and concomitant clinical attachment loss.
To be determined by testing subgingival plaque after the Screening Visit: Have detectable Pg in subgingival plaque as assessed by PCR (we will take sample of plaque at the Screening Visit).
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