Some adults that have heart valve replacement end up having their new valves fail. This leads them to need surgery to correct the issue. The goal of this study is to see if a new heart valve system is safe and effective for adults that have had their replacement heart valves fail. Read More

Adults 65 years or older
Have uncontrolled blood pressure

Many patients with aortic stenosis (AS) have surgery to replace the heart valve that is not working properly. However, surgical options always have higher risk than non-surgical options. Doctors are interested in developing a non-surgical way to replace heart valves in patients with AS. Read More

Adults 18 years or older
Have been diagnosed with aortic stenosis
Are in need of aortic valve replacement

Have you been diagnosed with aortic regurgitation (AR)? If so, you may be eligible for the ARTIST clinical trial. Read More

Adults 18 years or older
Have been diagnosed with moderate to severe aortic regurgitation (AR)

The University at Buffalo (UB) is looking for older adults that have uncontrolled blood pressure to join a study. The goal of this study is to see how safe and effective renal denervation procedures are in people with high blood pressure. Read More

Adults 65 years or older
Have uncontrolled blood pressure

Aortic regurgitation (AR) is a heart valve problem that happens when the aortic valve doesn’t fully close. This allows blood to leak backward into the heart. When AR becomes severe, it can cause symptoms like shortness of breath, feeling tired, dizziness, chest pain, irregular heartbeat, and swollen ankles or feet. Over time, severe, symptomatic AR can lead to heart failure. Surgery is often needed to fix or replace the valve. Read More

Adults 18 years or older
Have been diagnosed with severe aortic regurgitation (AR)

High blood pressure (BP) is a common condition that affects many adults. It causes your heart to have to work harder to pump blood throughout your body. If left untreated, it can lead to damage of blood vessels and the heart over time. This can lead to heart attack or stroke. Unfortunately, it can be challenging for adults to manage their high BP despite making lifestyle changes and taking medications. Read More

Adults 18 years or older
Have been diagnosed with high blood pressure (hypertension)
Are struggling to control their high blood pressure despite taking medication and attempting lifestyle changes

Aortic stenosis is a type of heart valve disease in which the valve is narrowed and does not open fully. This reduces or blocks blood flow from the heart to the rest of the body. Read More

Adults 18 years or older
Have had a TAVR procedure in the past that needs to be redone

Adults living with failing heart valves are at an increased risk for heart failure. In order to treat failing heart valves, many patients require open heart surgery. Researchers are interested in developing a new way to fix failing heart valves that is less invasive than open heart surgery. Read More

Adults 18 years or older
Have a bioprosthetic aortic valve that is failing and needs to be replaced
You fall in the high or greater risk category for open heart surgery

Heart failure affects about 6.7 million adults in the United States. It is a condition in which the heart cannot pump blood as well as it should. Common symptoms are: shortness of breath doing everyday activities, tiredness, dizziness, confusion, sadness, depression, swelling in the lower part of your body, upset stomach or swelling, little to no appetite, and sudden weight gain. Read More

Adults 18 years or older
Have been diagnosed with heart failure
Are experiencing symptoms of heart failure that affect your daily life

The heart has four valves that open and shut like doors, to help pump blood through your body. One of the four valves is called the aortic valve. The tissue from the valve, that opens and shuts like doors, can become stiff. The stiffness causes the opening of the valve to become smaller. As the opening becomes smaller, it makes it harder for the heart to pump blood. This condition is called aortic stenosis (AS). Read More

Adults 65 years or older
Have been diagnosed with moderate, calcific aortic stenosis