Congenital Adrenal Hyperplaysia Study
Protocol: STUDY00004614
Full Title
A Randomized, Double Blinded, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Reducing Supraphysiologic Glucocorticoud Use in Adult Subjects with Classic Congenital Adrenal Hyperplaysia
Description
This study enrolls people with Congenital Adrenal Hyperplasia (CAH), a rare condition that changes the body’s ability to create key hormones. To replace these important hormones, people who live with CAH need to take constant doses of steroids, which mimic hormones and help the body function. The purpose of this study is to learn about how safe and effective a non-steroid option is to treat CAH.

You will be in this study for between 38-72 weeks, with several clinic visits within this time. During in-person visits you will meet with the study team, answer questionnaires, and have blood drawn for testing. During the study you will take tildacerfont tablets alongside your steroid regimen, collect at-home saliva samples every week, and keep an electronic diary. Study takes place at the Diabetes and Endocrinology Research Center of WNY 1000 Youngs Rd Suite 105 Williamsville NY 14221.

Technical Description

To evaluate the effect of tildacerfont in reducing glucocorticoid use in subjects with CAH
Compensation: No
Eligibility
Adults ages 18-55
Has a diagnosis of Classic Congenital Adrenal Hyperplaysia due to 21-hydroxylase deficiency
You'll have been on a stable daily dose of steroids (glucocorticoids or mineralocorticoid) before starting the trial.
Please contact the study team for additional eligibility criteria.
Age Group: Adults
Principal Investigator: AJAY CHAUDHURI
Contact(s)
Arsalan Mustafa
arsalanm@buffalo.edu
+1 716-548-9493
Want to Learn More?
Let us know how the study team can reach you. If you do not hear back within 2 business days, reach out to the study team directly at the contact information above or email ctsiresearch@buffalo.edu and someone will assist you.