Investigation of lood Draw Assays to Quantitate Effects of Therapeutic Interventions in Patients with HPV-Induced Head amp Neck Cancer
This study enrolls people who have head and neck cancer or tumor. The purpose of this study is to learn about whether levels of HPV (Human Papillomavirus) and a protein (P16) are related to the way people respond to treatment for head and neck cancer.
We expect you will be in this research study for about 3 months. You will be asked to give a total of 3 blood samples at regular, routine visit blood draws during your cancer treatment. These samples will be taken prior to chemotherapy, after chemotherapy, and post-surgery. Study takes place at ECMC in Buffalo, NY.
Hypothesis: A liquid biopsy using peripheral blood draws can be used to detect and quantify p16 and HPV circulating tumor DNA (ctDNA) in Head & Neck Cancer patients and furthermore, liquid biopsies can be used an accurate marker of treatment response.
Aim 1] To determine if a liquid biopsy using peripheral blood draws can be used to detect and quantify p16 and HPV circulating tumor DNA (ctDNA) in Head & Neck Cancer patients
Aim 2] To seek correlations between the presence or absence, and levels of these biomarkers and initial treatment response.
Aim 3] To establish liquid biopsy as a means to select patients for de-escalation strategies during cancer treatment.
Aim 4] To assess the utility of liquid biopsy in cancer surveillance.
-Patients at least 18 years of age.
-Patients who have been diagnosed with head and neck squamous cell carcinoma.
-Patients who have a pre-treatment biopsy of a pathologically confirmed p16/HPV positive tumor.
Let us know how the study team can reach you. If you do not hear back within 2 business days, reach out to the study team directly at the
contact information above or email firstname.lastname@example.org and someone will assist you.
Your information will be shared only with the research study team for recruitment purposes and designated CTSI personnel for project quality
assurance and will remain confidential. Your information will be stored indefinitely. Should you no longer want this information to be provided
in the aforementioned ways, please contact email@example.com.