This study is recruiting patients diagnosed with rapid-onset dystonia-parkinsonism (RDP). RDP is a rare movement disorder. It has symptoms of both dystonia (lasting muscle contractions) and Parkinson’s Disease (presence of tremor in one hand and a stiffness or slowing of movement). Patients may develop RDP suddenly or gradually over time. Read More
1) Patients with known/suspected RDP gene mutation OR those who have been identified as carriers/family members of someone with an RDP gene mutation
2)Patients who were previously enrolled in an earlier version of this study
3) 18 months of age or older
4) Access to Wi-Fi and a smart device (for example, a smartphone, laptop, tablet)
The goal of this study is determine the difference in quality of life in tree nut-allergic patients before and after clearing of allergy label for subgroups of tree nuts compared to those who completely avoid all tree nuts. This will be done via questionnaires given to patients and parents at clinic visits. Read More
Patient ages 0 to 17 years seen at UBMD Pediatrics Allergy/Immunology, who have a diagnosis of a tree nut allergy to one or more of the aforementioned tree nuts will be eligible to enroll in the study
The goal of the UB Eating Among Teens Study (UB EATS) is to measure eating behaviors and neighborhood and household factors in 11 - 14-year-olds over the course of 3 years. Participation involves 7 visits to the UB Nutrition and Health Research Lab on South Campus over the 3-year period to answer questionnaires and eat snack foods. Low and middle-income families are encouraged to apply. Read More
-Adolescents ages 11 to 14
-Low to moderate income households
-No medical conditions or medications that impact appetite
-No allergies to study foods such as cookies, candy and potato chips
-Planning to live in the Western New York area for the next two years
-Willing to attend baseline and follow-up visits at a local research center
This study enrolls students who participate in the after-school program at a local Buffalo community location. The purpose of this study is to look at reading and literacy skills after a computer based newsletter program. Read More
-Children ages 10-13.
-Must be in the after-school program at a participating local Buffalo community center in grades 6-8.
-Must have access to a computer: laptop, Chromebook, or desktop with the capability to download Zoom.
-Must have internet access at home or center.
This study enrolls children and young adults with congenital anomalies of the kidney and urinary tract (CAKUT). The purpose of the study is to learn which gene mutation(s) may be responsible for this condition and to eventually find a gene therapy to treat this condition. Read More
Children and young adults ages 0-21 years old with CAKUT (congenital anomalies of the kidney and urinary tract) seen at Oshei Children's Hospital
Patient's family member without CAKUT.
This study enrolls children who are having an intracranial or spinal fusion procedure. The purpose of this study is to learn about the DNA of children who develop an infection after surgery. The results of this study may help us learn how to better control infections in children after surgery in the future. Read More
Children ages 5-15.
Are having an intracranial or spinal fusion procedure.
This study enrolls people with TRK fusion cancer. The purpose of this study is to learn more about the effectiveness of the drug VITRAKVI (generic name: larotrectinib) for TRK fusion cancer that has spread from the place where it started to other places in the body. TRK fusion cancer is a term used to describe a variety of common and rare cancers that are caused by a change to the NTRK (Neurotrophic Tyrosine Kinase) gene called a fusion. VITRAKVI is an approved drug that blocks the action of the NTRK gene fusion. Read More
Patients with TRK fusion cancer (locally advanced or metastatic solid tumor harboring an NTRK gene fusion).
Your physician has decided to treat you with larotrectinib.
This study enrolls children who have a mitochondrial disease. The purpose of this research is to learn more about mitochondrial diseases, including their genetic causes and the types of medical problems associated with them. Read More
Must have a known or suspected pathogenic mutation in mitochondrial DNA or a mitochondrial related gene in the chromosomal DNA.
This study enrolls children who are having orthodontic treatment and need a rapid maxillary expansion (RME) device. The purpose of this study is to learn about the effects of palatal expansion on jaw movement during sleep. Read More
-Children ages 7-14.
-Are under orthodontic care and need to use a rapid maxillary expansion (RME) device
This study enrolls high school students and teachers. The purpose of the study is to help students learn how to culture microbial organisms found in water samples from streams, rivers or lakes, and to teach about genome annotation, DNA sequencing and genomic DNA isolation. The study is also meant to help students learn more about scientific and health-related careers. Read More
-High School Biology (grades 9-12) teachers from Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Livingston, Monroe, Niagara, Ontario, Orleans, Steuben, Wayne, Wyoming and Yates counties/schools.
-Teachers must recruit their students; students cannot enroll in the study on their own.