The purpose of this study is to learn more about the advantages and disadvantages of two brief quitting smoking approaches that could be cost-effective in assisting individuals who suffer from serious mental illness. The first approach is brief advice combined with the use of nicotine gum and patches. The second approach uses an app on your smartphone combined with the use of nicotine gum and patches. Read More

Inclusion Criteria
(1) Current DSM-5 diagnosis of schizophrenia, schizoaffective, bipolar, or recurring major depressive disorder;
(2) Functional impairment as indicated by a score of_2 or greater on the WHODAS 8 item version
(3) Smoker as indicated by smoking  5 cigarettes per day over the past 6 months;
(4) Desire to quit smoking as indicated by self-reported serious...

We are studying metabolism while marching with a heavy military backpack in dry and humid environments. Your first 3 visits will consist of completing questionnaires, a health screening & a series of exercises. During the following 6 visits you will perform treadmill walking while carrying a heavy military backpack. Read More

Healthy, physically active females (18-39 y) who pass the Occupational Physical Assessment Test (OPAT) with at least a gray score in each task (significant job requirement) will be eligible to participate. To ensure that extraneous variables do not impact study results, subjects will be excluded from participation for any of the following reasons:
- History of cardiovascular, metabolic, resp...

Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More

-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.

Study to assess the effect of dapagliflozin as compared with placebo in patients with heart failure who have been stabilized during hospitalization for acute heart failure. Patients will be followed for a maximum of 2 months. Read More

1. Currently hospitalized with AHF with symptoms of AHF.
2. LVEF <40% within the past 12 months
3. Elevated NT-proBNP, >1600 pg/ml
4. > 18 years of age
5. eGFR >30

This clinical study investigates a new treatment for prostate cancer. ODM-208 (CYP11A1 inhibitor) is the oral study medication that will be taken together with oral glucocorticoid (dexamethasone) and mineralocorticoid (fludrocortisone) replacement therapy. The purpose of this study is to find a safe and effective dose of ODM-208 for the treatment of prostate cancer. The purpose of this study is also to use the results of this study to support development programs of CYP11A1 inhibitors in prostate cancer and other relevant indications. Read More

1) Males greater than or equal to 18 years. 2) Metastatic disease documented either by a positive bone scan, CT, PET/CT or MRI scan 3) Treatment with at least 1 line of taxane-based chemotherapy in castration-sensitive prostate cancer (CSPC) or in CRPC

-Adults ages 18-80
-Has a single unruptured target intracranial aneurysm (IA) located on the internal carotid artery (ICA) or its branches.

This study is being done to see if the Buffalo Concussion Physical Exam and the Tele-Brain Injury Screen can be safely used to identify brain injury and its impact on functioning in female survivors who have experienced intimate partner violence. The Buffalo Concussion Physical Exam is a non-invasive physical exam that examines neck/head area for any discomfort. This exam also tests standing balance and the ability to follow movements with eyes. The Tele-Brain Injury Screen tells us how individuals suspected of brain injury are feeling and whether the way they are feeling is interfering with their functioning. In essence, we want to understand if intimate partner violence could result in brain injury. We also want to understand the effects of brain injury on daily functioning and social functioning. Read More

18-60 years old
Proficient in English
Physical injury to head/neck/face or strangulation injury due to partner abuse within the past year
Reports of physical abuse (e.g., being thrown against an object, partner initiated fall resulting in head injury or any other reports of physical abuse resulting in whiplash injury) by an intimate partner within the past year
Phys...

This survey study examines how transgender and gender nonconforming individuals have experienced oral healthcare, how accessible such care is to them, and how they feel about receiving it. Read More

18 or greater years of age
self-identify as transgender or gender nonconforming

This is a study to evaluate the efficacy of Chemo Mouthpiece® in minimizing patient-reported symptoms associated with oral mucositis in cancer patients receiving chemotherapy. The Chemo Mouthpiece(R) is a novel device to make it easier to deliver cryotherapy (ice chips). Read More

Aged 18-80 years
Planned to receive at least 2 cycles of infused stomatotoxic chemotherapy regimens
Be willing and able to complete all study-related activities

The University at Buffalo (UB) School of Dental Medicine is looking for volunteers to join a gum disease study. The study aims to learn more about how harmful bacteria grow in the mouth and cause periodontal (gum) disease. We are interested in Porphyromonas gingivalis (P. ginivalis), a pathogen involved in gum disease. Read More

Adults aged 25 years or older Have at least 16 natural teeth Have the bacterium Porphyromonas gingivitis in their mouth Have gum disease (which will be determined by study staff) Do not wear braces or other orthodontic equipment Have not had periodontal treatment or surgery in the past year Not currently pregnant