This study enrolls adults ages 55-90 who have concerns about memory. The purpose of the Memory Improvement Through Nicotine Dosing (MIND) study is to learn whether Nicotine absorbed through the skin through a daily nicotine patch improves attention, learning, and memory in folks with mild cognitive impairment. Read More

Adults ages 55-90.
Must be a non-smoker.
Must have a memory concern as reported by participant, study partner, or clinician.
Study Partner is available who has frequent contact with the participant (e.g. an average of 10 hours per week or more), and can accompany the participant to most visits to answer questions about the participant.

This study enrolls children and adults who have tested positive for COVID-19. The purpose of this study is to collect and bank blood samples of people who have COVID-19. We will analyze these samples to understand more about the virus. Read More

Adults or children
Positive for SARS-CoV-2 or highly suspicious for SARS-CoV-2 (symptoms with known contact).

This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Read More

Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.

This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study. Read More

Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).

This study is for people undergoing surgery for mitral regurgitation (MR). Mitral regurgitation is a condition when your heart’s mitral valve does not close tightly which causes blood to flow backwards in your heart. The purpose of this study is to learn how safe and effective one value repair system is (the PASCAL System, an investigational device) compared to another one (the MitraClip System). Read More

Adults ages 18+.
Have severe degenerative mitral regurgitation, and are considered prohibitive risk for mitral valve surgery by your heart team.

This study enrolls healthy adults. The purpose is to determine a standard for how healthy people walk so that we can better help patients who have difficulty walking. Read More

Healthy adults ages 20-80
English speaking
Able to walk without assistance.

This study enrolls overweight people with knee arthritis. The purpose of this study is to learn if weight-loss surgery before total knee replacement leads to fewer short-term and long-term complications. Read More

Adults ages 22-75
Diagnosed with osteoarthritis of the knee and in need of total knee replacement
Overweight (determined by body mass index measurement)
Able to walk

The purpose of this study is to learn more about how nurse practitioner students and practicing nurse practitioners perceive the health needs Read More

Ages 18+
Understand and speak English
Have a state license as a nurse practitioner OR have a state license as a registered professional nurse while simultaneously seeking a nurse practitioner education
Have at least 3 months of professional practice in a setting that could potentially direct the care of adult lesbian, gay, bisexual, or transgender patients
Have nurse practitio...

This study enrolls healthy adults. The purpose of this study is to learn how people use memories and make decisions about their behavior. Read More

-Healthy adults ages 18-64.
-English spoken as first language.
-USA residents.
-Cannot be pregnant.

This study enrolls healthy adults. The purpose of this study is to learn how people use memories and make decisions about their behavior. Read More

Healthy adults ages 18-64.
English spoken as first language.
USA residents.
Cannot be pregnant.