Endometriosis-associated pelvic pain and infertility: Cellular mechanisms
For 18-45 year old women undergoing gynecology surgery at Kaleida Health. A sliver of tissue and a tablespoon of fluid will be removed from womb lining which will take less than 5 minutes. This tissue and pelvic fluid will be used to examine cells, and measure hormones / inflammatory proteins. Patients will also be told whether or not there is endometriosis.
This is a mechanistic cellular investigation of human peritoneal fluid, tissue and primary, subject-derived cell cultures to evaluate hormones, cytokines and growth factors involved in endometrial cell dysfunction associated with endometriosis. Women undergoing indicated surgical laparoscopy will be recruited. At the time of their procedure, pelvic fluid will be sampled, the eutopic (intrauterine) endometrium will be biopsied using a silastic catheter (Pipelle) and when available, portions of extirpated pathological samples will be de-identified, assigned endometriosis stage (or control if no endometriosis is noted) and transported to the laboratory. Primary cell cultures will be generated using established methods. Differential responsiveness of the cell cultures from endometriosis subjects vs. controls will be assessed.
-Reproductive age women (18-45 years old)
-Regular menstrual cycles
-Undergoing indicated gynecological surgery, including tubal sterilization, evaluation of pelvic pain or pelvic mass
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