We seek to expand the portfolio of evidence-based treatments for urologic chronic pelvic pain syndrome (UCPPS) by evaluating the immediate and longer-term efficacy of a brief version of cognitive behavioral therapy (CBT) as well as the active ingredients (mechanisms) explaining why, how, and for whom it is most beneficial. An effective and relatively simple ???across disorder??? or transdiagnostic treatment that targets simultaneously what UCPPS and frequently co-occurring (and complicating) disorders have in common rather than their differences would improve on conventional behavioral pain approaches whose narrower focus, length, cost and/or complexity have limited their transfer from well-controlled laboratory to ???real world??? settings accessible to more individuals in need. By capitalizing on cutting-edge cognitive science research that emphasizes the importance of how patients think, not simply what they think about, we plan to demonstrate how a parsimonious, transdiagnostic, mechanistically-driven behavioral treatment of low intensity can reduce both painful urinary and co-occurring nonurological symptoms with minimal clinician oversight and maximum patient engagement, safety and benefit.