This study enrolls overweight people with knee arthritis. The purpose of this study is to learn if weight-loss surgery before total knee replacement leads to fewer short-term and long-term complications. Read More
Adults ages 22-75
Diagnosed with osteoarthritis of the knee and in need of total knee replacement
Overweight (determined by body mass index measurement)
Able to walk
This study enrolls adults and children ages 12+ who have obesity due to rare genetic disorders. The purpose of this study is to learn whether treatment with the study drug, setmelanotide, helps people with those disorders lose weight. Read More
Adults and children ages 12+.
Rare genetic disease patient with genetically confirmed diagnosis.
Obese (measured by BMI).
This study enrolls children ages 12-17 with obesity. We are doing this study to look at how well a new medicine called semaglutide works in helping to lose weight. Read More
Children ages 12-17.
BMI over 95th percentile* OR less than the 85th percentile* with 1 weight related condition (treated or untreated): hypertension, dyslipidemia, obstructive sleep apnea or type 2 diabetes
**If diagnosed with type 2 diabetes at screening the following criteria apply in addition:
HbA1c less than 10.0% as measured by central laboratory at screening
We are looking for adults who are obese (BMI above 30) to be in a research study. The purpose of this study is to learn how a type of omega-3 fatty acid changes inflammation in the body before and after a high fat meal. Read More
Adults age 18-75.
Obese (BMI above 30).
LDL cholesterol of above 100 mg/dL.
Not taking any vitamins or antioxidants.
We are looking for adults who are planning to have bariatric surgery for a research study. The purpose of the study is to learn more about how behavioral and genetic differences among people can impact outcomes after surgery. Read More
Adults ages 18+.
Planning to undergo bariatric surgery.
We are looking for adults with type 1 diabetes for a research study. The purpose of the study is to see how well an already approved treatment for type 2 diabetes works for people with type 1 diabetes. Read More
Adults ages 18+.
Diagnosed with Type 1 diabetes.
Currently using an insulin pump or multiple daily injections of insulin.
We are looking for African American/Black or White men to participate in a research study. The purpose of the study is to learn more about health and wellness in these groups of people. Read More
Adult men ages 18+.
Men who identify as Black/African American or White.
A body mass index of 35 or higher (you can calculate your BMI here: https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html or contact the study staff)
Diagnosed with at least 2 of these 3 conditions: type 2 diabetes, hypertension or chronic kidney disease.