The University at Buffalo (UB) Department of Rehabilitation Science is looking for adults with spinal cord injuries (SCIs) for the nationwide ASPIRE (Assessing non-invasive Spinal Stimulation and PT/OT for motor Improvement Response with ExaStim) clinical study. The goal of this study is to see if a new type of treatment can help people with SCIs to regain arm/hand movement that was lost due to injuries. Read More

At least 22 years old Have had a spinal cord injury (specifically between C2 and T2 in the spine) Have limited ability to use their arms or hands Are able to participate in the study for 13 weeks

This study is recruiting volunteers for a dental study through the University at Buffalo (UB) Microbiome Center in the UB School of Dental Medicine. The study team is researching if they can make accurate copies of bacteria patterns in mouth plaque (the “stuff” that collects between gums and teeth). The results of the study will help dentists to better understand how gum disease develops and comes back over time. Read More

1. At least 21 years old 2. Have at least sixteen (16) teeth 3. Not currently pregnant 4. Not currently wearing braces or orthodontic appliances

The UB Jacobs School of Medicine and Biomedical Sciences, Division of Behavioral Medicine (DBM) is looking for adult volunteers to participate in the EPPIC (Easing Pelvic Pain Interventions Clinical Research Program). The goal of this National Institutes of Health (NIH)-funded study is to determine the effectiveness of different behavioral therapies for controlling urologic chronic pelvic pain syndrome (UCPPS), why they work, for whom they are most effective, and durability of treatment gains (or how long they last). This is a non-drug treatment study and volunteers will receive payment for their participation in the study. Read More

1) Male or females between the ages of 18-70 years old 2) Experience pelvic pain symptoms for at least 3 months 3) Diagnosis of interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPP) 4) Access to a telephone and computer/smartphone 5) Reliable transportation

Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More

-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.

Study to assess the effect of dapagliflozin as compared with placebo in patients with heart failure who have been stabilized during hospitalization for acute heart failure. Patients will be followed for a maximum of 2 months. Read More

1. Currently hospitalized with AHF with symptoms of AHF.
2. LVEF <40% within the past 12 months
3. Elevated NT-proBNP, >1600 pg/ml
4. > 18 years of age
5. eGFR >30

The University at Buffalo (UB) School of Dental Medicine is looking for volunteers to join a gum disease study. The study aims to learn more about how harmful bacteria grow in the mouth and cause periodontal (gum) disease. We are interested in Porphyromonas gingivalis (P. ginivalis), a pathogen involved in gum disease. Read More

Adults aged 25 years or older Have at least 16 natural teeth Have the bacterium Porphyromonas gingivitis in their mouth Have gum disease (which will be determined by study staff) Do not wear braces or other orthodontic equipment Have not had periodontal treatment or surgery in the past year Not currently pregnant

The University at Buffalo (UB) Department of Neurology is recruiting healthy adults and those with multiple sclerosis (MS) for a study. The goal of the study is to examine a new test of processing speed (or how quickly the brain understands and responds to information) that was developed for people diagnosed with MS. Read More

-Adults 18 years or older
-Have been diagnosed with multiple sclerosis (MS) OR are healthy adults
-Speak English

This study enrolls people who have been diagnosed with Tricuspid Regurgitation (TR). The purpose of this study is to look at the safety and effectiveness of this new investigational device compared to the standard medical treatment. Read More

Adults ages 18+
Diagnosed with Tricuspid Regurgitation/Insufficiency

This study enrolls people who have mitral regurgitation (MR). Mitral regurgitation happens when the heart’s mitral valve does not close tightly. The purpose of this trial is to evaluate a new investigational device called the Tendyne™ Mitral Valve System. The Tendyne Mitral Valve System is designed for the treatment of a diseased, damaged or malfunctioning mitral valve. This trial will collect information on how safe and effective this device is to treat a leaking mitral valve compared to the commercially available MitraClip® System. Read More

-Adults ages 18+.
-Have symptomatic, moderate-to-severe/severe mitral regurgitation (MR) or severe mitral annular calcification (MAC)
-Your medical providers have decided a transcatheter therapy is more appropriate than open surgery.

This study enrolls people who have been diagnosed with head and neck cancer and are being treated with neck radiation therapy. The purpose of this study is to find out the number of people who develop narrowing of their carotid arteries (Carotid Artery Stenosis) due to neck radiation and understand how tobacco use and diabetes effect the worsening of carotid artery stenosis. Read More

Adults age 18+
Diagnosis of neck cancer and undergoing one-sided neck radiation
Must have no history of stroke