This study is to evaluate the long-term safety and tolerability of daily valbenazine (20, 40, 60, or 80mg) for the treatment of chorea associated with Huntington's Disease (HD) for up to 104 weeks. This study will enroll approximately 120 medically stable male and female subjects with HD who previously completed study drug dosing during the maintenance period as well as the study visit at Week 14 for Study NBI-98854-HD3005. Read More
To participate in this study, subjects must meet the following criteria:
1. Participated in Study NBI-98854-HD3005 and
a) Study drug dosing completion of Study NBI-98854-HD3005, as demonstrated by completed study drug dosing during the dose maintenance period as well as the study visit at Week 14.
b) Early terminated Study NBI-98854-HD3005 for administrative reasons due to COVID-19...
This study will measure the change in blood pressure following 4 months of testosterone therapy with Natesto. A total of 218 subjects with a diagnosis of hypogonadism who successfully complete the 24-hour baseline blood pressure session will be included in the study. The total duration of study will be approximately 4 months. Compensation / Reimbursement to study participants. Read More
1. Male between 18 and 80 years of age, inclusive, with documented onset of
hypogonadism prior to age 65.
2. Serum total testosterone < 300 ng/dL based on 2 consecutive blood samples obtained no
greater than 1-4 weeks apart between 6 and 10 AM following an appropriate washout of
current androgen replacement therapy if not testosterone naive. Historical values from
the past 6 months may be use...
We plan to collect urine samples from patients with Parkinson's Disease, from which we can model the Parkinson's brain. Genetically, the neurons we generate from the urine will match that of the patient donor, making them an ideal way to screen for markers of disease. We will use our urine-derived neurons to assess differences between patient and healthy control cells, as well as a comparison of time-points from individual patients. This study will allow us to gain a clearer understanding of the altered neurochemical state that is so difficult to assess in Parkinson’s patients. Read More
Diagnosis of Parkinson's Disease (or spousal control), either with or without resting tremor
Aged between 40 and 99 years of age
Absence of renal disease
We are studying metabolism while marching with a heavy military backpack in dry and humid environments. Your first 3 visits will consist of completing questionnaires, a health screening & a series of exercises. During the following 6 visits you will perform treadmill walking while carrying a heavy military backpack. Read More
Healthy, physically active females (18-39 y) who pass the Occupational Physical Assessment Test (OPAT) with at least a gray score in each task (significant job requirement) will be eligible to participate. To ensure that extraneous variables do not impact study results, subjects will be excluded from participation for any of the following reasons:
- History of cardiovascular, metabolic, resp...
Patients who use cannabis on a regular basis may be at a greater risk for sedation-related complications. In our dental sedation suite, we routinely sedate patients for oral surgery three days per week. We have recently noted an increase in patients who use cannabis regularly. This study will gather self-reported cannabis use history via a questionnaire, and analyze sedation records to assess cannabis use's effect on sedation. Read More
-18 or greater years of age and report to our oral surgery clinic for treatment.
-Able to consent to their own medical treatment.
-Willing to sign informed consent and complete the questionnaire.
-Able to comprehend the content of the questionnaire and consent form in English.
We are seeking Transradial amputee’s participation in a research study aiming to evaluate a novel controller for a prosthetic wrist. This study investigates the performance of the controller during activities of daily living in a virtual reality environment. Upper limb movement and muscle activation will also be collected using Motion Capture Systems and different types of sensors. Study will be done at Furnas Hall 809, AWEAR Lab, University at Buffalo North Campus. Read More
- 18 years old or above and have unilateral or bilateral upper limp amputation
- Current and/or New user of any type of prosthetic device
- Non-user of prosthetic devices who have been previously fit but have chosen not to wear it
Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More
-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.
Study to assess the effect of dapagliflozin as compared with placebo in patients with heart failure who have been stabilized during hospitalization for acute heart failure. Patients will be followed for a maximum of 2 months. Read More
1. Currently hospitalized with AHF with symptoms of AHF.
2. LVEF <40% within the past 12 months
3. Elevated NT-proBNP, >1600 pg/ml
4. > 18 years of age
5. eGFR >30
We invite you to participate in this research study because you've been diagnosed with a spinal condition requiring surgery using pedicle screw instrumentation in your lumbar spine. Your surgeon plans to use the VersaTie tether to prevent breakdown above your spine surgery. The VersaTie tether provides a gradual transition from the unfused to fused spine. The study procedure will take place at Gates Vascular Institute. Read More
1. >18 years of age at the time of treatment
2. EOS full body or standing 36” AP & Lateral images of entire spine
3. Posterior spine fusion with pedicle screw fixation construct of 5 or more levels
4. Pedicle screw fixation to be supplemented proximally with NuVasive VersaTie system
5. Upper instrumented vertebra (UIV) terminating at a newly instru...
The purpose of the study is to see how best to educate people about kidney transplantation and donation. The ECMC kidney patient will get an email invitation to participate. Participant will then fill out a few online surveys and watch several short videos about kidney transplantation / donation for about an hour. Participant will be paid up to $200. Read More
Advanced kidney failure