This clinical trial is exploring the use of an investigational drug (sGC stimulator vericiguat/MK-1242) in patients with chronic heart failure. Specifically, trial doctors are interested in assessing the safety of this drug and if it works well to lower some of the risks of heart failure. All participants will be able to stay on their current heart failure medication during the 2-year trial period. Read More
1) History of chronic stable, NYHA class II to IV CHF
2) NT-proBNP 600 - 6000
3) LVEF of <40% assessed within 12 months before randomization
Study to assess the effect of dapagliflozin as compared with placebo in patients with heart failure who have been stabilized during hospitalization for acute heart failure. Patients will be followed for a maximum of 2 months. Read More
1. Currently hospitalized with AHF with symptoms of AHF.
2. LVEF <40% within the past 12 months
3. Elevated NT-proBNP, >1600 pg/ml
4. > 18 years of age
5. eGFR >30
This study enrolls people who have Mitral Regurgitation (MR) who will be having mitral valve surgery. The purpose of this study is to learn about the effectiveness of the MitraClip™ system for treating patients who are candidates for Mitral Valve (MV) repair surgery. We will compare the MitraClip™ system to MV repair surgery which is the current standard of care for this condition. Read More
-Adults age 75+ (OR if younger than 75 years, then has other conditions that make them eligible for the study).
-Diagnosed with severe mitral regurgitation.
-Your care team has confirmed that your mitral valve anatomy is suitable for percutaneous repair with the MitraClip device.
An early feasibility study to evaluate the safety and efficacy of Delphi Revascularization device for clot retrieval. This is for hospital patients with Anterior circulation ischemic stroke. Up to 8hrs of symptom onset or last known well time. Read More
At least 18 years of age at time of consent;
The patient or patient’s LAR has signed and dated an ICD using the Institutional Review Board (IRB) and Medtronic Approved ICD and agrees to comply with protocol requirements. Health Insurance Portability and Accountability Act of 1996 (HIPAA) authorization has been provided and signed by the patient or patient’s LAR
Has baseline N...
This study enrolls adults with a blockage in an artery in their heart that needs to be tested to determine if it should be treated. The purpose of this study is to collect data and measurements to find out if you need you need an interventional procedure to open your blood vessel or artery. Read More
Adults ages 18+.
Have at least 1 non-stented lesion in 1 or more major epicardial vessels of 40-90% angiographic stenosis.
This study enrolls people who have been diagnosed with a blood clot blocking an artery in their brain (stroke). The blocked artery is opened by removing the blood clot using a small catheter (thin tube) device that is inserted into an artery through your arm or leg that leads to your brain. The purpose of this study is to find out if this specific new investigational catheter (ZOOM) leads to improved outcomes at 90 days. Read More
Adults ages 18+
Diagnosed with a stroke
This study enrolls people who have been diagnosed with Tricuspid Regurgitation (TR). The purpose of this study is to look at the safety and effectiveness of this new investigational device compared to the standard medical treatment. Read More
Adults ages 18+
Diagnosed with Tricuspid Regurgitation/Insufficiency
This study enrolls older adults who may have a completely or partially blocked blood vessel(s) in their heart causing a type of heart attack known as a ST-elevation myocardial infarction (STEMI). This may need a medical procedure called “Percutaneous Coronary Intervention (PCI)” to open narrowed or blocked blood vessel(s). This is sometimes called an angioplasty or ‘balloon procedure’ often with stent placement at the same time. The purpose of this study is to learn about the safety and benefits of different types of treatment for this condition. Read More
Adults ages 60+.
You have had a significant ST-elevation myocardial infarction or left bundle branch block (LBBB).
Your physician plans to perform trans-radial Percutaneous Coronary Intervention (PCI).