Due to COVID-19, new enrollment in research studies will be greatly limited.
If you are interested in a study, there may be a longer waiting period to receive a response to your inquiry.
View the guidance for research participants for additional information.
This study enrolls adults who have had heart failure or heart attack or who are generally healthy. The purpose of this study is to learn more about how these types of cardiovascular issues happen at a biological level. We will do that by looking at the immune cells in the blood. Read More
Adults ages 18+
Generally healthy OR are presenting to the hospital with heart failure or acute myocardial infarction (heart attack).
This study enrolls adults with a common type of heart failure (called “preserved ejection fraction” or HFpEF) that has no proven treatment and is often the result of poorly controlled high blood pressure. The purpose of this study is to learn if the new investigational drug finerenone improves outcomes and is safe in patients with HFpEF. Read More
-Adults ages 40+.
-Diagnosed with heart failure (class II-IV).
This study enrolls adults who have been chosen to participate because they have carotid narrowing (a blockage) that may benefit from the use of the Neuroguard IEP System, a carotid stent and filter used during a medical procedure to open the blockage. Read More
-Adults ages 20-80.
-Have been diagnosed with carotid artery stenosis treatable with carotid artery stenting.
-Additional eligibility criteria apply.
This study enrolls adults who are scheduled to have an aortic valve replacement for disease the aortic valve called aortic stenosis. The Evolut PRO and Evolut PRO+ systems are FDA approved for treating aortic stenosis, so in this study we just want to collect data. The purpose of this study is to learn more about how well this device works. Read More
-Adults ages 18+.
-Have symptoms from aortic valve stenosis.
-Will be having aortic valve replacement.
This study enrolls people who have mitral regurgitation (MR). Mitral regurgitation happens when the heart’s mitral valve does not close tightly. The purpose of this trial is to evaluate a new investigational device called the Tendyne™ Mitral Valve System. The Tendyne Mitral Valve System is designed for the treatment of a diseased, damaged or malfunctioning mitral valve. This trial will collect information on how safe and effective this device is to treat a leaking mitral valve compared to the commercially available MitraClip® System. Read More
-Adults ages 18+.
-Have symptomatic, moderate-to-severe/severe mitral regurgitation (MR) or severe mitral annular calcification (MAC)
-Your medical providers have decided a transcatheter therapy is more appropriate than open surgery.
This study enrolls people who have had a stroke or who have epilepsy who are being seen at Buffalo General Hospital. We want to learn more about how a patient’s understanding of the disease, treatment and other factors prevent future medical events. Read More
Adults ages 18+.
Must have confirmed diagnosis of stroke or seizure disorder.
Presents for stroke or seizure at Buffalo General Medical Center.
This study enrolls people who are hospitalized with acute heart failure. The purpose of this study is to learn if it is safe and effective to start the study medication (empagliflozin) while a person is in the hospital for acute heart failure. Read More
-Adults ages 18+
-Currently hospitalized with primary diagnosis of acute heart failure
-Evidence of left ventricular ejection fraction, either reduced or preserved, in the 12 months
This study enrolls adults ages 18-65 who have the symptoms of an ischemic stroke. An ischemic stroke is caused by a clot in a blood vessel that blocks blood flow to a certain part of the brain. The purpose of this study is to learn more about if people with this type of stroke do better when their blockage is removed within 24 hours of the stroke starting. Read More
Adults ages 18-65.
Presenting to the hospital with symptoms consistent with an acute ischemic stroke.
We are looking for adults ages 18+ coming into Kaleida Health’s Gates Vascular Institute who have recently had a certain kind of mild stroke for this study (acute ischemic stroke that presents with mild symptoms). You would need to be enrolled into the study within 6 hours of when your symptoms begin. The purpose of this study is to find out which factors associated with the stroke make the condition worse. This will help us identify high-risk patients in the future. You will participate in this study for about 90 days. During the study you will not be asked to do anything additional- all the procedures involved in this study are routinely done with patients with stroke. If you decide to be in this study, we will gather data (for example, your history and vital signs) from your medical Read More
Diagnosed with acute ischemic stroke.
At Kaleida Health-Gates Vascular Institute.
Enrolled within 6 hours from when symptoms begin.
This study is for people undergoing surgery for mitral regurgitation (MR). Mitral regurgitation is a condition when your heart’s mitral valve does not close tightly which causes blood to flow backwards in your heart. The purpose of this study is to learn how safe and effective one value repair system is (the PASCAL System, an investigational device) compared to another one (the MitraClip System). Read More
Adults ages 18+.
Have severe degenerative mitral regurgitation, and are considered prohibitive risk for mitral valve surgery by your heart team.