Due to COVID-19, new enrollment in research studies will be greatly limited.
If you are interested in a study, there may be a longer waiting period to receive a response to your inquiry.
View the guidance for research participants for additional information.
This study enrolls adults with tricuspid valve regurgitation. This is a condition where the valve between the two right heart chambers does not close correctly. The purpose of this study is to learn about patients' preferences for managing and treating this condition. The results of the study may help other patients with tricuspid valve disease, as well as healthcare professionals providing care to patients with tricuspid valve disease, in the future. Read More
Adults ages 21+
Diagnosis of tricuspid valve regurgitation (moderate or greater)
Untreated or receiving medical management and still symptomatic
This study enrolls people who have been diagnosed with an ischemic stroke, a type of stroke where an artery in your brain has been blocked by a blood clot. The purpose of this study is to collect information (data) on medical devices used in the procedure to remove the blood clot and look at the success and related to different medical devices. Read More
Adults ages 18+
Diagnosed with ischemic stroke and planning to undergo procedure to remove blood clot
This study enrolls people who have been diagnosed with Tricuspid Regurgitation (TR) and have Heart Failure symptoms which are not under control despite treatment with current available therapies. The purpose of this study is to compare a new investigational (experimental) device plus optimal drug therapy with optimal drug therapy alone. Read More
Adults ages 18+
Diagnosed with moderate or greater Tricuspid Regurgitation/Insufficiency with Heart Failure symptoms
The purpose of this research study is to compare the use of apixaban to aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes. Read More
Adults ages 45+
Have been diagnosed with an ischemic stroke of undetermined cause in the last 120 days.
Currently admitted to Gates Vascular Institute.
This study enrolls people who have been diagnosed with a subarachnoid hemorrhage (SAH), a type of brain bleed. The most common complication after SAH is blood vessel narrowing (vasospasm) in the brain. The purpose of this study is to find out if an investigational (experimental) device, which has not yet been approved by the FDA, is safe and can help treat patients who develop vasospasm after treatment of a SAH. Read More
People ages 18+
Developed vasospasm complications after treatment for SAH
This study enrolls people who have had a stroke in the past 2 weeks. This research is being done to figure out whether treatment for sleep apnea in people who have had a stroke or transient ischemic attack (TIA or "mini stroke"), improves recovery from stroke and helps prevent future stroke, heart problems, and death. Read More
Adults ages 18+.
Are at an inpatient at an enrolling site (Buffalo General Hospital or Gates Vascular Institute).
Have had an ischemic stroke or TIA within the past 14 days.
Use a CPAP machine.
This study enrolls adults ages 18-65 who have the symptoms of an ischemic stroke. An ischemic stroke is caused by a clot in a blood vessel that blocks blood flow to a certain part of the brain. The purpose of this study is to learn more about if people with this type of stroke do better when their blockage is removed within 24 hours of the stroke starting. Read More
Adults ages 18-65.
Presenting to the hospital with symptoms consistent with an acute ischemic stroke.
We are looking for adults ages 18+ coming into Kaleida Health’s Gates Vascular Institute who have recently had a certain kind of mild stroke for this study (acute ischemic stroke that presents with mild symptoms). You would need to be enrolled into the study within 6 hours of when your symptoms begin. The purpose of this study is to find out which factors associated with the stroke make the condition worse. This will help us identify high-risk patients in the future. You will participate in this study for about 90 days. During the study you will not be asked to do anything additional- all the procedures involved in this study are routinely done with patients with stroke. If you decide to be in this study, we will gather data (for example, your history and vital signs) from your medical Read More
Diagnosed with acute ischemic stroke.
At Kaleida Health-Gates Vascular Institute.
Enrolled within 6 hours from when symptoms begin.
This study enrolls adults who have have a patent foramen ovale (PFO) and have had a stroke. The purpose of this study is to look at closing the PFO to reduce your risk for another stroke using a market-approved medical device called a septal occluder. Read More
Adults ages 18-70.
Patient has been evaluated by a neurologist and diagnosed with an ischemic stroke presumed to be an embolic stroke of undetermined source (ESUS) within the last 365 days prior to enrollment.
Patient has presence of a patent foramen ovale (PFO).
This study is for people undergoing surgery for mitral regurgitation (MR). Mitral regurgitation is a condition when your heart’s mitral valve does not close tightly which causes blood to flow backwards in your heart. The purpose of this study is to learn how safe and effective one value repair system is (the PASCAL System, an investigational device) compared to another one (the MitraClip System). Read More
Adults ages 18+.
Have severe degenerative mitral regurgitation, and are considered prohibitive risk for mitral valve surgery by your heart team.