The University at Buffalo (UB) Department of Medicine is recruiting people who have patent foramen ovale (PFO) and experience migraines for a clinical trial. People with PFO have a hole in their heart. The goal of the study is to see if a new device (the GORE CARDIOFORM Septal Occluder) can help to treat migraines in people with PFO. It is also investigating the safety of the study device. Read More

Adults 18 years or older Have been diagnosed with patent foramen ovale (PFO) Experience migraine headaches

The University at Buffalo (UB) Department of Communicative Disorders and Sciences is looking for adults diagnosed with Parkinson’s Disease who are participating in the SPEAK OUT! therapy program for study. The goal of the study is to see if there are different benefits for SPEAK OUT! participants who receive in-person versus telehealth sessions. Read More

Adults over the age of 18 years old Have been diagnosed with Parkinson's Disease Are receiving therapy from the SPEAK OUT! Program

The University at Buffalo (UB) Department of Communicative Disorders and Sciences is looking for people with hyperacusis (cannot tolerate loud noises) for an in-person study. The goal of the study is to develop a more reliable method for diagnosing hyperacusis. Read More

Adults over the age of 18 years old Have been diagnosed with hyperacusis (cannot tolerate loud noises) Able to attend an in-person study visit to the UB South Campus

The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries to participate in an exercise study. The goal of the study is to learn more about the brain and bodily responses to exercise in people with and without spinal cord injuries. The results of this study will hopefully improve the quality of life for adults with spinal cord injuries. Read More

Adults between the ages of 18-55 years old Adults with a spinal cord injury (at least 6 months after the initial injury) Adults without a spinal cord injury Reliable transportation to attend two study visits on the UB South Campus (at Main Street and Bailey Avenue)

Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More

-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.

Participants will be asked questions about a new cognitive processing test (how fast they can think). This study involves a single visit which takes about 20-minutes at the Conventus Medical Center in Buffalo. 50 multiple sclerosis patients and 50 healthy people will be enrolled. Read More

Physician established diagnosis of multiple sclerosis
18 years of age or older
Able to read and speak English
Not pregnant

This study enrolls adults who have had a brain hemorrhage within the last 7 days. The purpose of the study is to learn whether it is better to keep taking or stop taking the medication statin after having a brain bleed. Read More

Adults ages 50+.
Have had bleeding in the brain (brain hemorrhage) within the last 7 days.
Were taking a statin drug.
People who may be eligible for this study will be contacted by study staff directly. Eligible participants will be inpatients of Buffalo General/Gates Vascular Institute.

This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Read More

Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.

This study uses a phone app to track people’s life values and goals. It aims to help people improve their quality of life by completing their goals with the help of trained life coaches. It includes two in-person visits, a few phone check-ins, short tests, and questionnaires. Read More

60+ years old, Own smart phone, and Have no history of substance use problems or mental health/ neurological conditions.

This study enrolls adults who have had a recent stroke or stroke symptoms. The purpose of this study is to compare how well the study drug (tenecteplase) works for people with stroke symptoms. Read More

-Adults ages 18+.
-Have been diagnosed with a stroke or stroke symptoms.
-Please contact the research team for other eligibility criteria.