We are looking for adults ages 18-40 for this study. We are looking for people in general good health and also people who have had a history of blast exposure and blunt head trauma. The purpose of this study is to learn more about balance in people with a history of blast exposure and blunt head trauma compared to healthy people. You will participate in this study for one session that lasts about 3 hours. During the study you will complete balance, vision, and stability tests in our lab. Study visit takes place in the Department of Rehabilitation Science lab at UB's South Campus. Participants will be compensated. Read More
-Adults ages 18-40.
-Generally healthy OR have had a history of impact brain injury/head trauma in past ten years.
This study enrolls adults with Relapsing Multiple Sclerosis. The purpose of this study is to learn about changes in cognition that happen while being treated with the experimental medication RPC1063 (also known as ozanimod). Read More
- Adults ages 18-65.
- Have at least 5 years since time of RMS diagnosis.
- Have no clinically relevant cardiovascular conditions.
This study is to evaluate the long-term safety and tolerability of daily valbenazine (20, 40, 60, or 80mg) for the treatment of chorea associated with Huntington's Disease (HD) for up to 104 weeks. This study will enroll approximately 120 medically stable male and female subjects with HD who previously completed study drug dosing during the maintenance period as well as the study visit at Week 14 for Study NBI-98854-HD3005. Read More
To participate in this study, subjects must meet the following criteria:
1. Participated in Study NBI-98854-HD3005 and
a) Study drug dosing completion of Study NBI-98854-HD3005, as demonstrated by completed study drug dosing during the dose maintenance period as well as the study visit at Week 14.
b) Early terminated Study NBI-98854-HD3005 for administrative reasons due to COVID-19...
We plan to collect urine samples from patients with Parkinson's Disease, from which we can model the Parkinson's brain. Genetically, the neurons we generate from the urine will match that of the patient donor, making them an ideal way to screen for markers of disease. We will use our urine-derived neurons to assess differences between patient and healthy control cells, as well as a comparison of time-points from individual patients. This study will allow us to gain a clearer understanding of the altered neurochemical state that is so difficult to assess in Parkinson’s patients. Read More
Diagnosis of Parkinson's Disease (or spousal control), either with or without resting tremor
Aged between 40 and 99 years of age
Absence of renal disease
Participants with or without multiple sclerosis are needed for this research study on audio-visual cognition. Participants will be asked to complete some short questionnaires and cognitive tasks over the span of approximately 2-3 hours. All testing will be completed in one session at the University at Buffalo's Division of Cognitive and Behavioral Neurosciences Laboratories. Read More
-Age range 20-65 years
-Normal Hearing and Vision
-DO NOT have the following: severe psychiatric disorder, alcohol or substance abuse or dependence, history of traumatic head injury, neurological disturbances other than multiple sclerosis.
We invite you to participate in this research study because you've been diagnosed with a spinal condition requiring surgery using pedicle screw instrumentation in your lumbar spine. Your surgeon plans to use the VersaTie tether to prevent breakdown above your spine surgery. The VersaTie tether provides a gradual transition from the unfused to fused spine. The study procedure will take place at Gates Vascular Institute. Read More
1. >18 years of age at the time of treatment
2. EOS full body or standing 36” AP & Lateral images of entire spine
3. Posterior spine fusion with pedicle screw fixation construct of 5 or more levels
4. Pedicle screw fixation to be supplemented proximally with NuVasive VersaTie system
5. Upper instrumented vertebra (UIV) terminating at a newly instru...
Adult patients with cerebral palsy will be walking on ground and a treadmill. Participants will wear a belt on their waist with sensors connected to a robot. There will be unpleasant sounds generated to provide cues to change walking pattern. Study will take place at UB for six sessions and will take two hours for each session. Read More
This study enrolls people who have suffered a stroke in the past 24 hours. The purpose of this study is to learn if a patient can benefit from a clot removal procedure if they have a stroke scale of 5 or lower. Read More
-Adults ages 18+
-Diagnosed with acute ischemic stroke and have an objective neurological deficit.
An early feasibility study to evaluate the safety and efficacy of Delphi Revascularization device for clot retrieval. This is for hospital patients with Anterior circulation ischemic stroke. Up to 8hrs of symptom onset or last known well time. Read More
At least 18 years of age at time of consent;
The patient or patient’s LAR has signed and dated an ICD using the Institutional Review Board (IRB) and Medtronic Approved ICD and agrees to comply with protocol requirements. Health Insurance Portability and Accountability Act of 1996 (HIPAA) authorization has been provided and signed by the patient or patient’s LAR
Has baseline N...
Participants will be asked questions about a new cognitive processing test (how fast they can think). This study involves a single visit which takes about 20-minutes at the Conventus Medical Center in Buffalo. 50 multiple sclerosis patients and 50 healthy people will be enrolled. Read More
Physician established diagnosis of multiple sclerosis
18 years of age or older
Able to read and speak English