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Study for Older Adults Diagnosed with Alzheimer’s Disease
Protocol: STUDY00009458
Full Title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for the Treatment of Cognitive Impairment Associated with Mild to Moderate Alzheimer's Disease (MINDSET 2)
Description
Alzheimer’s disease (AD) slowly destroys our ability to think and remember things. Doctors do not fully understand what causes AD. But we know that brain cells stop working properly. These cells eventually become damaged and lose the ability to connect with each other.

The University at Buffalo is studying if a new medicine can treat memory and thinking problems that develop from AD. Adults aged 60 to 85 years old diagnosed with mild to moderate AD can apply.

Participants will be in the study for up to 34 or 58 weeks. They will complete the following:
-a screening period (2-4 visits over 5 weeks)
-a treatment period (about 9 visits over 24 weeks)
-a follow-up period (1 visit after 4 weeks)
-they may also be asked to participate in an optional 24-week open-label extension (OLE) period.

After the screening period, they will be randomly assigned (which happens by chance, like flipping a coin) to take either:
-the study medicine
-a placebo (a pill with no medicine).

If they were to participate in the OLE, they would receive the study medicine for the second six months of the study.

Participants and study partners will each receive $100 for study visits they atte
Compensation: Yes
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Compensation may include cash, checks, gift cards, debit cards, or incentives like gift baskets, technology items, or merchandise.
Eligibility
-Adults 60-85 years old that have been diagnosed with mild to moderate Alzheimer's Disease
-Have someone that can attend the study visits with you
Age Group: Adults
Principal Investigator: KINGA SZIGETI
Contact(s)
Nicholas Audino
ncaudino@buffalo.edu

Want to Learn More?

Let us know how the study team can reach you. If you do not hear back within 2 business days, then reach out to the study team directly at the contact information above and someone will assist you.

Your information will be shared only with the research study team and administrative staff for recruitment and will remain confidential. Your information will be stored until study recruitment is closed. Should you no longer want this information to be provided in the aforementioned ways, please contact the study team directly.

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