Study for Children in the Pediatric Intensive Care Unit
Transfusion associated pathophysiology in multiple organ dysfunction syndrome
This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study.
The purpose of this research is to determine the processes that lead to the development and progression of multiple organ dysfunction syndrome (MODS) . Previous research studies have shown that MODS may be more prevalent among children who receive blood transfusions. The goal of this study is to discover proteins and genes that may predispose critically ill children to the development and progression of MODS. Ultimately, this will help researchers develop strategies and treatments to reduce the occurrence of MODS in critically ill children and may lead to safer transfusion practices.
Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).
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