This study enrolls people who have mitral regurgitation (MR). Mitral regurgitation happens when the heart’s mitral valve does not close tightly. The purpose of this trial is to evaluate a new investigational device called the Tendyne™ Mitral Valve System. The Tendyne Mitral Valve System is designed for the treatment of a diseased, damaged or malfunctioning mitral valve. This trial will collect information on how safe and effective this device is to treat a leaking mitral valve compared to the commercially available MitraClip® System. Read More

-Adults ages 18+.
-Have symptomatic, moderate-to-severe/severe mitral regurgitation (MR) or severe mitral annular calcification (MAC)
-Your medical providers have decided a transcatheter therapy is more appropriate than open surgery.

This study enrolls people who need tube shunt implantation for the treatment of their severe glaucoma. The purpose of this study is to learn which type of tube shunt (a device used during the surgery) works the best. Read More

Adults ages 18+.
Have significant uncontrolled glaucoma despite medical, laser or previous surgery that requires tube shunt implantation.
Are scheduled for glaucoma tube shunt implantation surgery.

This study enrolls high school students and teachers. The purpose of the study is to help students learn how to culture microbial organisms found in water samples from streams, rivers or lakes, and to teach about genome annotation, DNA sequencing and genomic DNA isolation. The study is also meant to help students learn more about scientific and health-related careers. Read More

-High School Biology (grades 9-12) teachers from Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Livingston, Monroe, Niagara, Ontario, Orleans, Steuben, Wayne, Wyoming and Yates counties/schools. -Teachers must recruit their students; students cannot enroll in the study on their own.

This study enrolls people who are HIV positive who are taking certain medication. If a person take Stribilid® or Genvoya®, there may be changes in the way their body uses or removes other medications. We want to study another approved treatment, Biktarvy®, that we believe is less likely to affect how the body handles other medications that a person is currently taking. This switch may improve quality of life. Read More

-Adults ages 18+.
-Positive for HIV.
-Taking current antiretroviral therapy GenvoyaTM or StribildTM for HIV-1 infection.
-Taking at least 1 or more other prescription medications.

This study is looking for women ages 18-24 who are in college. The purpose of this study is to get feedback about program designed for friends to help protect one another against sexual assault. Read More

Adult women ages 18-24.
Enrolled in a 4 year college or university

This study enrolls people who have been diagnosed with head and neck cancer and are being treated with neck radiation therapy. The purpose of this study is to find out the number of people who develop narrowing of their carotid arteries (Carotid Artery Stenosis) due to neck radiation and understand how tobacco use and diabetes effect the worsening of carotid artery stenosis. Read More

Adults age 18+
Diagnosis of neck cancer and undergoing one-sided neck radiation
Must have no history of stroke

This study enrolls healthy, physically-active adults. The purpose of this study is to learn if exercising in a hot environment can better help the body adjust to higher altitudes where the air is thinner. Travel to higher altitudes takes weeks for the body to adjust, however, military personnel may not have enough time to adjust. This study may lead to valuable information that can benefit our troops. Read More

Healthy males aged 18-29
Physically-active and in good fitness

This study enrolls adults ages 55-90 who have concerns about memory. The purpose of the Memory Improvement Through Nicotine Dosing (MIND) study is to learn whether Nicotine absorbed through the skin through a daily nicotine patch improves attention, learning, and memory in folks with mild cognitive impairment. Read More

Adults ages 55-90.
Must be a non-smoker.
Must have a memory concern as reported by participant, study partner, or clinician.
Study Partner is available who has frequent contact with the participant (e.g. an average of 10 hours per week or more), and can accompany the participant to most visits to answer questions about the participant.

This study enrolls children and adults who have tested positive for COVID-19. The purpose of this study is to collect and bank blood samples of people who have COVID-19. We will analyze these samples to understand more about the virus. Read More

Adults or children
Positive for SARS-CoV-2 or highly suspicious for SARS-CoV-2 (symptoms with known contact).

This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Read More

Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.