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Project Number
2R01AI05911104A
Project Title
ARRA: VIRULENCE DETERMINANTS OF S. AUREUS BACTEREMIA
Funds Allocatted
$558,617
Total Award Amount
$1,084,201
Principal Investigator
GILL, DR. STEVEN R.
PI Department
Oral Biology
Awarding Agency
NAT'L INS. OF ALLERGY & INFECTIOUS DIS.
Abstract
Infections caused by Staphylococcus aureus span a wide clinical spectrum, ranging from asymptomatic nasal carriage to endocarditis, bone and joint infections and lethal shock. Increasing rates of S. aureus infection and the emergence of community-acquired strains drive the need for an increased understanding of the virulence determinants of this emerging pathogen and evaluating the role they play in outcome of patients with S. aureus bacteremia. Evaluating the role of these virulence determinants in humans was limited by the absence of a large, well-characterized collection of bloodstream S. aureus isolates. Such a clinical resource was developed by Vance Fowler (Co-Investigator), when he created one of the world.