Websites and Databases for Genetically Modified Mice

Taconic Website

http://taconic.com
Taconic has multiple databases of commercially available microinjected and targeted mutation mice. Some models are available through the Taconic Transgenic Models (TTMs) as off the shelf, readily available commercial models. There are also models available through the Emerging Models program http://taconic.com/emerging/listing.htm, and a database of over 1,000 single gene knockout models through the Lexicon database http://taconic.lexgen.com/taconic/index.html. Custom model generation is also available through a collaboration with Artemis http://www.taconic.com/Access/artemis.htm.

International Mouse Strain Resource (IMSR)

http://www.informatics.jax.org/imsr/index.jsp
The IMSR is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice. The goal of the IMSR is to assist the international scientific community in locating and obtaining mouse resources for research. Note that the data content found in the IMSR is as it was supplied by data provider sites.

Mutant Mouse Regional Resource Center (MMRRC)

http://www.mmrrc.org
The MMRRC is a respository of mouse stocks and ES cell line collections serving the world-wide genetics and biomedical research community for the benefit of human health. The MMRRC program is supported by the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH, DHHS). The purpose of the program is to ensure the continued availability of scientifically valuable, genetically engineered mice and to distribute these mice to qualified researchers studying human and animal biology and disease.

International Gene Trap Consortium (IGTC)

http://www.genetrap.org
The International Gene Trap Consortium (IGTC) represents all publicly available gene trap cell lines, which are available on a non-collaborative basis for nominal handling fees. Researchers can search and browse the IGTC database for cell lines of interest using accession numbers or IDs, keywords, sequence data, tissue expression profiles and biological pathways.

Oak Ridge National Laboratory Mutant Mouse Database

http://bio.lsd.ornl.gov/mouse
Oak Ridge National Laboratory (ORNL) has a large collection of mouse stocks, most of which propagate mutations induced (over a period of several decades) by radiations or chemicals in various stages of male or female gametogenesis. These mutations may range from single base-pair changes to rearrangements of various sizes, depending on mutagen and germ-cell stage. These mutant stocks are available either as live mice or as cryopreserved embryos/gametes/tissues.

Lexicon OmniBank eBiology Program

http:/www.lexicon-genetics.com/discovery/omnibank.htm
Lexicon has used gene trapping technology to create the OmniBank library of more than 270,000 embryonic stem cell clones. Each OmniBank mouse clone contains a single genetic mutation that can be used to produce knockout models of gene function. It is estimated that the OmniBank library currently contains clones representing more than half of all genes in the mammalian genome and it may be the largest library of its kind.

Trans NIH Mouse Initiative

http://www.nih.gov/science/models/mouse/
While not a database or repository of mice, this website has information on multiple mouse initiatives by the NIH including the NIH Knock Out Mouse Project (KOMP) and a listing of available NIH lines from Lexicon and Deltagen, with full phenotypic data on each line.

European Mouse Mutant Archive (EMMA)

http://www.emma.rm.cnr.it/
The European Mouse Mutant Archive (EMMA) is a non-profit repository for the collection, archiving (via cryopreservation) and distribution of relevant mutant strains essential for basic biomedical research.

A Large Scale Mutagenesis Program at RIKEN (Japan)

http://www.gsc.riken.go.jp/Mouse/main.htm
Using mouse ENU mutagenesis, RIKEN has developed a database of mutant mice that have been screened based on their phenotype. Searches for mice can be performed either by the gene identified or by the phenotype found. Mice are preserved at RIKEN and available through the center under an MTA.