VITA
Minda R. Lynch
National Institute on Drug Abuse
Behavioral Sciences Research Branch
Division of Neuroscience and Behavioral Research
6001 Executive Boulevard, Room 4282, MSC 9555
Bethesda, Maryland 20892-9555
Phone: 301-435-1322
Fax: 301-594-6043
E-mail: mlynch1@nida.nih.gov
EDUCATION
B.S. Psychology (1975) Virginia Commonwealth University, Richmond, VA.
M.S. Biopsychology (1978) Virginia Commonwealth University, Richmond, VA.
Ph.D. Biopsychology/Neuroscience (1982) VCU/MCV, Richmond, VA.
POSTDOCTORAL TRAINING
Veterans Administration Medical Center, Research and Development Service, and State University of New York
Health Science Center, Department of Psychiatry and Behavioral Science, Syracuse, NY:
Neuropsychopharmacology (Dr. Robert J. Carey), 1985-1987.
Medical College of Virginia, Department of Pharmacology and Toxicology, Richmond, VA: Neuropharmacology
(Dr. Susan E. Robinson), 1983-1984.
Concordia University, Center for Studies in Behavioral Neurobiology, Psychology Department, Montreal, Quebec,
Canada: Behavioral Neuroscience (Dr. Roy A. Wise), 1982-1983.
PROFESSIONAL EXPERIENCE/ACADEMIC APPOINTMENTS
National Institutes of Health, National Institute on Drug Abuse, Division of Neuroscience and Behavioral Research,
Behavioral Research Branch, Rockville, MD: Health Science Administrator, 1998 to present.
State University of New York Health Science Center at Syracuse, Syracuse, NY, Dept. Psychiatry and Behavioral
Sciences: Assistant Research Professor, 1985-1991 and Associate Research Professor, 1991-1998; and Faculty,
Graduate Neuroscience Program, 1989-1998.
Syracuse University, Dept. Psychology, Syracuse, NY: Adjunct Associate Professor, 1992-1998.
Veterans Administration Medical Center, Research and Development Service, Syracuse, NY: Staff Research
Psychopharmacologist, 1987-1998.
Medical College of Virginia, Department of Pharmacology and Toxicology, Richmond, VA: Laboratory Specialist
in Behavioral Pharmacology (Dr. Robert Balster), 1979-1981.
Southside Virginia Training Center for the Mentally Retarded, Petersburg, VA: Training Center Team Leader
in charge of large scale Behavioral Modification Programs, 1976.
Tucker Psychiatric Clinic, Chippenham Hospital, Richmond, VA: Inpatient Psychiatric Technician, 1977-1979.
Monroe Center, Department of Mental Health and Mental Retardation, Richmond, VA: Behavioral Technician for
implementation of outpatient Parent Enhancement Program, 1975.
GRANTS AWARDED
S.U.N.Y. Health Science Center at Syracuse, Hendricks Foundation: "Dopaminergic substrates of brain stimulation
reward: Anhedonia and performance", 1985-1986, $15,499 (Postdoctoral Fellow).
Scottish Rite Schizophrenia Research Program: "Neuropathology of mesolimbic dopamine neurons and abnormal
behavior", 1986-1988, $48,167 (Principal Investigator).
National Institute on Drug Abuse: "Dopaminergic substrates of brain stimulation reward: Anhedonia and
performance", 1987, $27,000 (NRSA).
Veterans Administration Merit Review: "Limbic dopamine and animal models of schizophrenic symptomatology",
1987-1990, $197,300 (Principal Investigator).
S.U.N.Y. Health Science Center at Syracuse, Hendricks Foundation New Faculty Award, "Neurotransmitter
dynamics of chronic stimulant behaviors", 1988-1989, $25,000 (Principal Investigator).
Veterans Administration Merit Review: "Neuroadaptation in mesolimbic dopamine systems", 1990-1992,
$184,800 (Principal Investigator).
Veterans Administration Merit Review: "Cortico-subcortical DA interactions and schizophrenic symptomatology",
1992-1996, $468,900 (Principal Investigator).
Veterans Administration Merit Review: "PFC 5-HT and Limbic D3 receptors: Relevance for chronic
schizophrenia?", 1997-2000, $530,500 (Principal Investigator).
INVITED LECTURES
"Mesocorticolimbic dopamine systems and psychopathology", Syracuse University Psychology Department,
Cognitive Neuroscience Program, Oct. l990.
"Neuroadaptation in central mesolimbic dopamine systems of the rat", NIMH Neuropsychiatry Branch,
Neuroscience Center at Saint Elizabeth's Hospital, Jan. l99l.
"Schizophrenia and the D1 receptor: Focus on negative symptoms", SUNY at Buffalo, Graduate Neuroscience
Program, April, 1993.
"Neurochemical systems in psychopathology", Syracuse University Dept. of Psychology, Cognitive Neuroscience
Program, Mar. 1995.
“Current perspectives in research and treatment of schizophrenia” (Annual Dan Kirk Memorial Lecture) and
“Schizophrenia: Past, Present and Future” (Invited Address, 25th Annual Psychology Undergraduate Research
Conference), Marist College, Poughkeepsie, NY, Nov. 1999.
COMMITTEE MEMBERSHIPS AND OFFICES
"GHB Antidote Committee", Division of Treatment Research and Development, NIH/National Institute on Drug
Abuse, Bethesda, MD, 2000.
Prevention Work Group (Co-chair), NIH/National Institute on Drug Abuse, Bethesda, MD, 1999.
Institutional Review Board, Veterans Administration Medical Center, Syracuse, NY, 1987-99.
Research and Development Service Executive Committee, Veterans Administration Medical Center, Syracuse,
NY, 1992-95.
Biohazard Safety Committee, Veterans Administration Medical Center, Syracuse, NY, 1996-97.
Acting Secretary, Executive Committee, Sigma Xi Scientific Research Society, Syracuse Chapter, Syracuse,
NY, 1988-89.
Neuroscience Program Executive Committee, SUNY Health Science Center, Syracuse, NY, 1992-1998.
Neuroscience Seminar Committee (Chair), SUNY Health Science Center, Syracuse, NY, 1991.
Neuroscience “Neurofest” Committee, SUNY Health Science Center, Syracuse, NY, 1992-96.
Search Committee for Neuroscience Program Director, SUNY Health Science Center, Syracuse, NY, 1995.
SCIENTIFIC MEETINGS
¨
NIDA Behavioral Science Work Group
“Early Career Pathways: Opportunities for Behavioral Researchers” Series
“Motives for Behavior: From Neurobiological to Cognitive Perspectives”, American
Psychological Society, June 1999 (Co-chair with Dr. Arthur Horton)
“Career Pathways in Behavioral Neuroscience”, Society for Neuroscience, Oct. 1999
(Co-chair with Drs. Lynda Erinoff, Joseph Frascella and Lucinda Miner)
APA “Conference on Drug Abuse”
“Career Development Workshop”, American Psychological Association, Aug. 2000
(Co-chair with Drs. Lucinda Miner, Mark Swieter and David Shurtleff)
¨
NIDA Prevention Work Group
“Preclinical, Clinical and Preventive Perspectives on Protection”, Society for Prevention Research, June
1999 (Co-chair with Dr. Bill Bukoski)
¨
NIDA Cognitive Science Work Group
“Frontal Cortical Function and Drug Abuse”, Society of Biological Psychiatry, May 2000 (Co-chair with
Drs. Susan Volman and Joseph Frascella)
¨
NIDA Neuroscience Consortium
“All about GHB”, Cutting Edge Seminar Series, June 2000 (Co-chair with Dr. Jerry Frankenheim)
¨
NIDA Division of Neuroscience and Behavioral Research
“Cross sensitization between drugs of abuse”, Society for Neuroscience Satellite Symposium, Nov. 2000
(Co-chair with Dr. Nancy Pilotte)
¨
NIDA Behavioral Sciences Research Branch
“Interoceptive Drug Cues: Beyond Drug Discrimination”, Aug. 1999 (Chair)
¨
Other/Miscellaneous
“The Role of Experience-Dependent Plasticity in Psychopathology: Implications for Prevention”, Society
for Prevention Research, June 2000 (Dr. Diana Fishbein, Chair and Dr. Minda Lynch, Discussant)
NIH INITIATIVES
Request for applications, DA-01-002 “Development of behavioral methods for drug abuse studies in the mouse”,
(written with Dr. Susan Volman, lead)
THESIS
Dopaminergic involvement in the aversion to oral methadone. Department of Psychology, Virginia
Commonwealth University, Richmond, Virginia. December, 1974.
DISSERTATION
Influence of contextual cues on the self-administration of oral etonitazene. Dissertation Abstracts International,
October 1983B, 44(4): 1275.
PUBLICATIONS
1. Lynch, M.R., Porter, J.H. and Rosecrans, J.A. Schedule-induced versus home cage ethanol consumption: Influence
of food deprivation. Bull. Psychonom. Soc., 1982, 19: 45-47.
2. Landauer, M.R., Lynch, M.R., Balster, R.L. and Kallman, M.J. Trichloromethane-induced taste aversions in
mice. Neurobehav. Toxicol. Teratol., 1982, 4: 305-309.
3. Porter, J.H., Hornbuckle, P.A., Lynch, M.R. and Crutchfield, D.V. The effects of complete and unilateral
neocortical lesions on schedule-induced polydipsia. Physiol. and Behav., 1982, 25: 177-181.
4. Kallman, M.J., Lynch, M.R. and Landauer, M.R. Conditioned taste aversions to several halogenated
hydrocarbons. Neurobehav. Toxicol. Teratol., 1983, 5: 23-27.
5. Lynch, M.R., Porter, J.H. and Rosecrans, J.A. Latent inhibition in the oral aversion to methadone. Pharmacol.
Biochem. Behav., 1984, 20: 467-472.
6. Lynch, M.R. and Porter, J.H. Failure to block opiate effects of oral etonitazene with naltrexone administration
during 24 hour choice testing. Bull. Psychonom. Soc., 1985, 23: 241-244.
7. Lynch, M.R. and Wise, R.A. Relative effectiveness of pimozide, haloperidol and trifluoperazine on self-
stimulation rate-intensity functions. Pharmacol. Biochem. Behav., 1985, 23: 777-780.
8. Lynch, M.R., Rice, M.A. and Robinson, S.E. Dissociation of locomotor depression and brain AChE activity
after soman, sarin or DFP. Pharmacol. Biochem. Behav., 1986, 24: 941-947.
9. Lynch, M.R. and Carey, R.J. Within session data. Biol. Psychiat., 1986, 21: 573-57.
10. Lynch, M.R. and Carey, R.J. Environmental stimulation promotes recovery from haloperidol-induced extinction
of open field behavior in rats. Psychopharmacology, 1987, 92: 206-209.
11. Lynch, M.R., Kuhn, H-G and Carey, R.J. Chronic haloperidol-amphetamine interactions and mesolimbic
dopamine. Neuropsychobiol., l988, 19: 97-103.
12. Lynch, M.R. and Carey, R.J. Sensitization of chronic neuroleptic behavioral effects. Biol. Psychiat., l988, 24:
950-952.
13. Lynch, M.R. and Carey, R.J. Amphetamine-induced rotation reveals post 6-OHDA lesion neurochemical
reorganization. Behav. Brain Res., l989, 32: 69-74.
14. Lynch, M.R. and Carey, R.J. Mesolimbic dopamine and early post-6-OHDA lesion enhanced responses to d-
amphetamine. Pharmacol. Biochem. Behav., l989, 32: 577-580.
15. Lynch, M.R. and Carey, R.J. Chronic low-dose haloperidol effects on self-stimulation rate-intensity functions.
Psychopharmacology, l990, 102: 122-129.
16. Lynch, M.R. Dissociation of autoreceptor activation and behavioral consequences of low-dose apomorphiner
treatment. Prog. Neuropsychopharmacol. Biol. Psychiat., 1991, 15: 689-698.
17. Lynch, M.R. and Woo, J. Enhanced haloperidol-induced prolactin elevation with chronic neuroleptic treatment
in the rat. Life Sci., 1991, 49: 1721-1729.
18. Lynch, M.R. Scopolamine enhances expression of an amphetamine-conditioned place preference. Neuroreport,
1991, 2: 715-718.
19. Lynch, M.R. Behavioral evidence for dopamine receptor subsensitivity following chronic haloperidol.
Neuropsychobiol., l99l, 24: 102-108.
20. Lynch, M.R. Schizophrenia and the D1 receptor: Focus on negative symptoms. Prog. Neuro-
psychopharmacol. Biol. Psychiat., 1992, 16: 797-832.
21. Tanquary, J., Lynch, M.R. and Masand, P. Obsessive-compulsive disorder in relation to body dysmorphic
disorder. Am. J. Psychiat., 1992, 149: 1283-1284.
22. Lynch, M.R. and Ormsby, J.L. Acute haloperidol attenuates the hypomotility induced with 7-hydroxy-DPAT.
Neuroreport, 1997, 8: 611-615.
23. Lynch, M.R. Selective effects on prefrontal cortex serotonin by dopamine D3 receptor agonism: Interaction
with low-dose haloperidol. Progr. Neuropsychopharmacol. Biol. Psychiat., 1997, 21:1141-1153.
PRESENTATIONS AND ABSTRACTS
1. Davis, A., Randolph, N. and Lynch, M. Parent Enhancement Program Symposium. Richmond Area
Association of Behavior Therapists Workshop, Richmond, VA, May, 1975.
2. Porter, J.H., Lynch, M.R., Burnet, M.G. and Bryant, Jr., W.E. Is schedule-induced polydipsia a useful method
for studying alcoholism? 24th Annual Southeastern Psychological Association Convention, Atlanta, GA,
March, 1978.
3. Lynch, M.R., Porter, J.H. and Rosecrans, J.A. The role of Pavlovian conditioning in the oral aversion to
methadone. 25th Annual Southeastern Psychological Association Convention, New Orleans, LA, March,
1979.
4. Landauer, M.R., Balster, R.L., Lynch, M.R. and Minnema, D. Effects of psychoactive drugs on the social
behavior of sexually naive and experienced mice. Division 28 Paper Session, American Psychological
Association 88th Annual Convention, Montreal, Quebec, Aug., 1980.
5. Landauer, M.R., Lynch, M.R. and Balster, R.L. Trichloromethane-induced taste aversion as an index of
toxicity in mice. Fed. Proc., 1981, 40:698.
6. Porter, J.H., Hornbuckle, P.A., Crutchfield, D.V. and Lynch, M.R. The effects of complete and unilateral
neocortical lesions on schedule-induced polydipsia. 52nd Annual Eastern Psychological Association
Convention, New York, NY, April, 1981.
7. Landauer, M.R., Jordan, S., Lynch, M.R. and Balster, R.L. Investigatory responses of male mice toward female
conspecifics following administration of naloxone and/or morphine. 13th Annual Conference on
Reproductive Behavior, Nashville, TN, June, 1981.
8. Lynch, M.R. and Kallman, M.J. Conditioned taste aversion as an index of toxicity in acute and subchronic
exposure to drinking water contaminants. 53rd Annual Eastern Psychological Association convention,
Baltimore, MD, April, 1982.
9. Lynch, M.R., Porter, J.H. and Johnson, D.N. Failure to block the opiate effects of etonitazene with naltrexone
in rats. Soc. Neurosci. Abs., 1982, 8:590.
10. Lynch, M.R. and Porter, J.H. The effect of body weight, environment and naltrexone injections on oral
etonitazene intake. 54th Annual Eastern Psychological Association Convention, Philadelphia, PA, April,
1983.
11. Lynch, M.R. and Porter, J.H. The influence of contextual cues on subsequent preference for oral
etonitazene. Soc. Neurosci. Abs., 1983, 9:276.
12. Lynch, M.R. and Wise, R.A. Shifts in brain stimulation reward rate-intensity functions after administration of
various D-2 antagonists. 55th Annual Eastern Psychological Association Convention, Baltimore, MD, April,
1984.
13. Lynch, M.R., Rice, M.A. and Robinson, S.E. Central cholinesterace inhibition and behavioral depression
produced by intrastriatal DFP. Soc. Neurosci. Abs., 1984, 10:808.
14. Lynch, M.R., Rice, M.A. and Robinson, S.E. ACh-E inhibition and behavioral depression following
intrastriatal DFP, Soman or Sarin. Eastern Psychol. Assoc. Abs., 1985, 56:39.
15. Lynch, M.R., Deveaugh-Geiss, J., Kuhn, G. and Carey, R.J. Acute haloperidol administration facilitates
habituation processes. Biol. Psychiat. Abs., 1985, 4:102.
16. Lynch, M.R. and Carey, R.J. Bilateral 6-OHDA lesions of mesolimbic terminals selectively enhance
spontaneous and scopolamine-induced locomotor behavior. Soc. Neurosci. Abs., 1985, 11:551.
17. Lynch, M.R., Deveaugh-Geiss, J. and Carey, R.J. Behavioral dopaminergic hypersensitivity following
neurochemical lesion of the olfactory tubercle in rats. Soc. Biol. Psychiat. Abs., 1986, 41:217.
18. Lynch, M.R. and Carey, R.J. Haloperidol-induced extinction in a paradigm without operant reinforcement
contingencies. Eastern Psychol. Assoc. Abs., 1986, 57:25.
19. Lynch, M.R. and Carey, R.J. Haloperidol differentially antagonizes amphetamine-induced shifts in threshold
for brain stimulation and locomotor activity. Soc. Neurosci. Abs., 1986, 12:937.
20. Deveaugh-Geiss, J., Lynch, M.R. and Carey, R.J. Contralateral rotation to amphetamine following unilateral
lesions of olfactory tubercle dopamine. Soc. Neurosci. Abs., 1986, 12:1226.
21. Lynch, M.R., Kuhn, H-G and Carey, R.J. Selective effects of chronic low-dose d-amphetamine treatment on
mesolimbic dopamine. Abs. Inter. Catecholamine Symp., 1987, 6:l27.
22. Lynch, M.R. and Carey, R.J. Sensitization of self-stimulation and spontaneous motor activity reductions after
chronic low-dose haloperidol treatment. Soc. Neurosci. Abs., 1987, 13:1546.
23. Carey, R.J. and Lynch, M.R. Time course of neuropharmacological reorganization of striatal function
following unilateral 6-hydroxydopamine lesions. Soc. Neurosci. Abs., 1987, 13:663.
24. Lynch, M.R. and Carey, R.J. Chronic neuroleptic tolerance and sensitization in the curve shift brain stimulation
reward paradigm. Soc. Neurosci. Abs., l988, 14: 1102.
25. Carey, R.J. and Lynch, M.R. Hypersensitivity of the 6-hydroxydopamine treated hemisphere to amphetamine
persists for one week postoperative. Soc. Neurosci. Abs., l988, 14: 664.
26. Lynch, M.R., Haskins, C. and Woo, J. Dopamine autoreceptor supersensitivity and postsynaptic subsensitivity
with chronic neuroleptic treatment. Soc. Neurosci. Abs., l990, l6: 588.
27. Lynch, M.R. and Scala Rodriguez, E.M. Scopolamine blockade of amphetamine-induced CPP. Soc. Neurosci.
Abs., 17: 1040, 1991.
28. Ryer, H.I., Woo, J. and Lynch, M.R. Enhanced prolactin elevation with chronic low-dose haloperidol in the rat.
Soc. Neurosci. Abs., 17: 688, 1991.
29. Lynch, M.R., Tanquary, J., Masand, P., Thomas, F.D. and Dewan, M.J. Clomipramine-associated
normalization of SPECT asymmetry in OCD. IBRO World Congress of Neurosci., 3: 331, 1991.
30. Dewan, M., Falen, S., Szeverenyi, N., Masand, P., Tanquary, J., Lynch, M. and Thomas, F.D. Simple surface
markers for aligning single photon emission computed tomography (SPECT) and magnetic resonance (MRI)
images. Biol. Psychiat., 31: 123A, 1992.
31. Masand, P., Thomas, F.D, Tanquary, J.F, Wasenko, J., Lynch, M.R., Dewan, M., Major, L.F. Do SPECT
findings in schizophrenia have clinical relevance? Biol. Psychiat., 33: A124-A124, 1993.
32. Lynch, M. and Ormsby, J.L. Chronic low-dose haloperidol effects on D3 induced hypomotility. Soc. Neurosci.
Abs., 22:1188, 1996.
AD HOC REFEREE
|
Journals
|
Pharmacology Biochemistry and Behavior
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Journal Neuroscience
Methods
|
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Psychopharmacology
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Physiology and
Behavior
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Biological Psychiatry
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Behavioral and Neural Biology
|
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Progr. Neuropsychopharmacol. Biol.
Psychiat.
|
Life Sciences
|
|
Grant Proposals
|
Ad hoc referee, Department of Veterans Affairs, Alcohol
and Drug Dependence
|
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Merit Review Board, Spring 1995.
|
COMMUNITY SERVICE
Alcohol and Other Drug Abuse Advisory Council to the Office of the County Executive, Montgomery County,
Maryland, 2001-2003.
Special Awards Judge, "Excellence in Neuroscience", Museum of Science and
Technology Science Fair, Syracuse, NY, 1997.
TEACHING EXPERIENCE
Psychology Department, Virginia Commonwealth University, Richmond, VA
¨
Teaching Assistant, Experimental Psychology (Psy 317 and 318, three labs) and Psychological Statistics (Psy
214, one lab), 1977-1979
¨
Adjunct Faculty, Developmental Psychology (3 sections,) Reading Efficiency (4 sections), Psychological
Statistics (3 sections), and Grad/Undergrad Physiological Psychology* (2 sections), 1979-1982
¨
Supervision of teaching assistants
S.U.N.Y. Health Science Center, Syracuse, NY: Research Training and Sponsorship
¨Diemut Stemmer, Undergrad Research Fellow, Univ. Düsseldorf Institute of Psychology, Spring 1987
¨Cheryl Bernstein, SUNY Summer Undergraduate Research Training Program, 1989
¨Lisa Posner, Summer Research Fellow, Cornell University, School of Veterinary Science, 1989
¨Sanjiv Kayastha, Cornell University, Pre-Med Student Research Trainee, Summer 1991
¨Eugene Lee, ESM High School, Research Volunteer, Summer 1992
¨Maureen Goldman, MSII, Research Work-Study, Summer 1993
¨Donna Saatman, MSII, Research Work-study, Summer 1994
¨Philip Ondicin, MSIV, PhD Research Track, Spring 1996
¨Miranda Harmon, Syracuse University, Pre-Med Student Research Trainee, 1996-97
S.U.N.Y. Dept. Psychiatry and Behavioral Science, Syracuse, NY: Teaching Activities
¨MSIII Junior Clerkship: "Addiction and Drug Abuse", 1986
¨Biological Psychiatry Seminar Series for Residents: "Neurochemistry and Behavior", 1987
¨Grand Rounds: "Dopamine in Schizophrenia: Challenging Traditional Concepts", 1992
¨Research Presentations for Residents: "Clozapine", 1992; "Animal Models of Human
Psychopathology", 1993
¨MSII Behavioral Science: "The Biologic Bases of Schizophrenia", 1994; "Behavioral Neurochemistry",
1995-97; "Limbic System and Psychopathology", 1997
¨MSI Neuroscience: "Limbic System, Neurotransmitters and Psychopathology" (Clinical correlation),
1996-1997
S.U.N.Y. Graduate Neuroscience Program, Syracuse, NY: Teaching Activities
¨Neuroscience Proseminar, 1990-96
¨Behavioral Neuroscience: "Behavioral Pharmacology", 1991 and 1992
¨Aspects in Cognitive and Behavioral Neuroscience: (Course coordinator), 1996
¨Colloquia: "Neurotransmitters in Basal Ganglia", 1990; "Mechanisms in Human Psychopathology:
Schizophrenia", 1993
¨Seminar Series: "Movement, Motivation and Psychopathology", 1991
Psychology Department, Syracuse University, Syracuse, NY